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Pregled bibliografske jedinice broj: 489832

Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles


Hranjec, Marijana; Starčević, Kristina; Kraljević Pavelić, Sandra; Lučin, Pero; Pavelić, Krešimir; Karminski-Zamola, Grace
Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles // European journal of medicinal chemistry, 46 (2011), 6; 2274-2279 doi:10.1016/j.ejmech.2011.03.008 (međunarodna recenzija, članak, znanstveni)


Naslov
Synthesis, spectroscopic characterization and antiproliferative evaluation in vitro of novel Schiff bases related to benzimidazoles

Autori
Hranjec, Marijana ; Starčević, Kristina ; Kraljević Pavelić, Sandra ; Lučin, Pero ; Pavelić, Krešimir ; Karminski-Zamola, Grace

Izvornik
European journal of medicinal chemistry (0223-5234) 46 (2011), 6; 2274-2279

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Benzimidazoles; Schiff bases; antiproliferaive evaluation; UV/Vis and fluorescence spectroscopy

Sažetak
A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by 1H and 13C NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
062-0620238-0223 - Sortiranje MHC-I molekula na staničnoj membrani i endocitoznim odjeljcima (Pero Lučin, )
125-0982464-1356 - Novi heterocikli kao antitumorski i antivirusni ("pametni") lijekovi (Marijana Hranjec, )
335-0000000-3532 - Uloga IGF2 i signalni putovi nizvodno u karcinomima pluća čovjeka (Sandra Kraljević Pavelić, )
335-0982464-2393 - Molekularna obilježja miofibroblasta Dupuytrenove bolesti (Krešimir Pavelić, )

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb,
Sveučilište u Rijeci - Odjel za biotehnologiju

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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