engleski

Formation of D-penicillamine in the reaction of penicillins with hydrazines

The epimerisation of D-benzylpenilloic acid in aprotic solvents was studied. D-Penicillamine was obtained in high yield and purity in the reaction with phenylhydrazine. The lack of reactivity of N-acyl-D-benzylpenilloic acids with phenylhydrazine indicate formation D-penicillamine via the open chain imine derivative.

D-penicillamine; D-benzylpenilloic acid; epimerisation

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