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Linoleic acid peroxidation vs. isomerization : a biomimetic model of free radical reactivity in the presence of thiols


Mihaljević, Branka; Tartaro, Ivana; Ferreri, Carla; Chatgilialoglu, Chryssostomos
Linoleic acid peroxidation vs. isomerization : a biomimetic model of free radical reactivity in the presence of thiols // Organic & biomolecular chemistry, 9 (2011), 3541-3548 doi:10.1039/C1OB05083D (međunarodna recenzija, članak, znanstveni)


Naslov
Linoleic acid peroxidation vs. isomerization : a biomimetic model of free radical reactivity in the presence of thiols

Autori
Mihaljević, Branka ; Tartaro, Ivana ; Ferreri, Carla ; Chatgilialoglu, Chryssostomos

Izvornik
Organic & biomolecular chemistry (1477-0520) 9 (2011); 3541-3548

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Lipid peroxidation; isomerization; linoleic acid; micelle

Sažetak
Biomimetic models of free radical-induced transformation of PUFA, such as micelles and liposomes, have been used for the study of lipid peroxidation and lipid isomerization. Free radical reactivity of thiol compounds is the common link of the two processes, since lipid peroxidation is inhibited by thiols, due to their H-donating ability, whereas lipid isomerization is catalyzed by S-centered radicals. In this paper the two processes a compared for the first time, in solution and under biomimetic conditions, demonstrating that hydroperoxides and trans lipids are formed at comparable extent as result of oxidative free radical conditions. The biomimetic model of micelles of linoleic acid, prepared by addition of a non-ionic surfactant (TWEEN®-20) and 2-mercaptoethanol as the amphiphilic thiol, was irradiated by ionizing radiations up to 400 Gy under various conditions. In air-equilibrated solutions, the cis-trans isomerization process was observed with a catalytic cycle of 370 together with a substantial amount of hydroperoxides (LOOH). The effect of micelle size was also studied in order to envisage the effect of the supramolecular organization for the outcome of the two processes, and in particular, for the positional preference of the double bond isomerization.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982904-2954 - Fizičko-kemijski učinci ionizirajućih zračenja u materijalima (Branka Mihaljević, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Citiraj ovu publikaciju

Mihaljević, Branka; Tartaro, Ivana; Ferreri, Carla; Chatgilialoglu, Chryssostomos
Linoleic acid peroxidation vs. isomerization : a biomimetic model of free radical reactivity in the presence of thiols // Organic & biomolecular chemistry, 9 (2011), 3541-3548 doi:10.1039/C1OB05083D (međunarodna recenzija, članak, znanstveni)
Mihaljević, B., Tartaro, I., Ferreri, C. & Chatgilialoglu, C. (2011) Linoleic acid peroxidation vs. isomerization : a biomimetic model of free radical reactivity in the presence of thiols. Organic & biomolecular chemistry, 9, 3541-3548 doi:10.1039/C1OB05083D.
@article{article, year = {2011}, pages = {3541-3548}, DOI = {10.1039/C1OB05083D}, keywords = {lipid peroxidation, isomerization, linoleic acid, micelle}, journal = {Organic and biomolecular chemistry}, doi = {10.1039/C1OB05083D}, volume = {9}, issn = {1477-0520}, title = {Linoleic acid peroxidation vs. isomerization : a biomimetic model of free radical reactivity in the presence of thiols}, keyword = {lipid peroxidation, isomerization, linoleic acid, micelle} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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