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Cervical squamous cell carcinoma in situ with per continuitatem expansion into endometrium and myometrium: Case report

The development of cervical cancer occurs in about 90% of cases over precancerous lesion, in about 10% without any sign (spray - cancer). Microinvasive squamous cell carcinoma of the cervix is well-known entity that is defined as carcinoma with invasion of less than 5mm, which invade the stroma and rarely metastasizes. Microinvasive squamous cervical carcinoma with superficial spread along the entire length of the endometrium of the uterus is extremely rare phenomenon that has been described in literature less than 20 times. It is even rarer case of microinvasive squamous cervical carcinoma with superficial spread to the endometrium of the uterus and early infiltrating growth, which so has so far only once been described previously. We report the case of 67-year-old patient, who was admitted for surgery, total hysterectomy with bilateral salpingoovariectomy due to PAPA proved cervical squamous cell carcinoma. The conisation was previously done in 2005 for carcinoma in situ of the cervix, with the free edges in PHD findings. In the 2009 we made planned surgical procedure and PHD finding confirmed the CIS squamous cell carcinoma of the cervix, which per continuitatem spread to the entire lining of the uterus, replaced the endometrium and invaded the uterine body to less than ½ of its thickness. Given that a total of 27 described secondary squamous cell carcinoma of the endometrium and 35 primary carcinoma, the studies are limited to case reports. Prognosis given the small number of reported cases is not yet possible, but considering the usual cancer prognostic factors (number of mitoses, degree of differentiation, lymph nodes, etc.) can be assumed that the after surgery was fairly good. This is a unique case of continuous expansion and invasion of cervical squamous cell carcinoma in situ that until today has not been described. Prognosis is not known, but the treatment approach should be to perform total hysterectomy with bilateral salpingoovariectomy.

CIS squamous cell carcinoma; per continuitatem spread; uterus; case report

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