engleski

“Microarray expression analysis of Dupuytren´s contracture”

Dupuytren´s disease (DD) is a connective tissue disorder characterized as nodular palmar fibromatosis that causes permanent contraction of one or more fingers. It has a well understood pathology but its etiology remains elusive. Surgical treatment remains the only gold standard the disease treatment. However, it does not eliminate processes that lead to the disease symptoms appearance, and therefore, about 10 % of patients have recurrence and require a new surgery. Some of the risk factors connected with DD are trauma, diabetes, alcoholism, epilepsy and liver disease. In addition, men are 10 times more likely to develop the contracture and more than 25% of older population will become affected by DD as well. We employed a high-throughput technology, the DNA microarray, to screen the entire genome for the changes in gene expression in diseased tissue as to characterize DD at a molecular level and find those genes that might be involved in of disease pathogenesis. We analyzed the obtained transcriptomics results in a biological context of protein changes revealed by our previous proteomic profiling of DD tissue samples. Important signaling molecules and signaling pathways arose from our analysis that might be central to the DD pathogenesis.

Dupuytren's contracture; microarray

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