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Pregled bibliografske jedinice broj: 486773

Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort


Fučić, Aleksandra; Stojković, Ranko; Miškov, Snježana; Želježić, Davor; Marković, Darko; Gjergja, Romana; Katić, Jelena; Jazbec, Anamarija; Ivičević Bakulić, Tomislav; Demarin, Vida
Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort // Reproductive toxicology, 30 (2010), 4; 613-618 doi:10.1016/j.reprotox.2010.08.008 (međunarodna recenzija, članak, znanstveni)


Naslov
Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort

Autori
Fučić, Aleksandra ; Stojković, Ranko ; Miškov, Snježana ; Želježić, Davor ; Marković, Darko ; Gjergja, Romana ; Katić, Jelena ; Jazbec, Anamarija ; Ivičević Bakulić, Tomislav ; Demarin, Vida

Izvornik
Reproductive toxicology (0890-6238) 30 (2010), 4; 613-618

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Antiepileptic drug; genotoxicology; micronucleus assay; newborn; mouse; transplacental

Sažetak
Antiepileptic drugs (AED) as transplacental agents are known to have adverse effects on fetal development. Genotoxicity of AEDs is still not fully understood. The aim of present study was to investigate the transplacental genotoxicity of valproate on animal model and in 21 mothers and their newborns receiving AED. In both studies, in vivo micronucleus (MN) assay was used. Pregnant dams were exposed to Na-valproate (100 mg/kg) on gestational days 12-14. Dams and pups receiving Na-valproate showed a significantly increased MN frequency (5.17±1.17/1000 ; 5.20±1.48/1000) compared to the control (1.0±0.58/1000 ; 1.67±1.03/1000). In mother/newborn study a significant increase of MN frequency was detected in newborns of mothers taking AEDs (3.09± 0.49/10 000) compared to the referent newborns (1.56 ±0.22/10 000). The results of this study suggest that AEDs may act as transplacental genotoxins. Launching the mother/newborn cohorts for genotoxicological monitoring may give a significant new insight in health effects of AEDs.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Projekt / tema
022-0222148-2137 - Genotoksičnost kemijskih i fizikalnih agensa prirodnog i antropogenog podrijetla (Vilena Kašuba, )
098-0982464-2390 - Novi terapijski modaliteti u liječenju malignih bolesti (Ranko Stojković, )
134-1340036-0033 - Uloga genetskih markera u razvoju cerebralne aterosklerotske bolesti (Vida Demarin, )
134-1340036-0034 - Funkcijska dijagnostika moždane cirkulacije (Arijana Lovrenčić-Huzjan, )
134-1340036-0035 - Uloga vaskularnih čimbenika rizika u patogenezi Alzheimerove bolesti (Zlatko Trkanjec, )

Ustanove
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
KBC "Sestre Milosrdnice"

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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