Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort (CROSBI ID 166587)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Fučić, Aleksandra ; Stojković, Ranko ; Miškov, Snježana ; Želježić, Davor ; Marković, Darko ; Gjergja, Romana ; Katić, Jelena ; Jazbec, Anamarija ; Ivičević Bakulić, Tomislav ; Demarin, Vida Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort // Reproductive toxicology, 30 (2010), 4; 613-618. doi: 10.1016/j.reprotox.2010.08.008

Podaci o odgovornosti

Fučić, Aleksandra ; Stojković, Ranko ; Miškov, Snježana ; Želježić, Davor ; Marković, Darko ; Gjergja, Romana ; Katić, Jelena ; Jazbec, Anamarija ; Ivičević Bakulić, Tomislav ; Demarin, Vida

engleski

Transplacental genotoxicity of antiepileptic drugs: animal model and pilot study on mother/newborn cohort

Antiepileptic drugs (AED) as transplacental agents are known to have adverse effects on fetal development. Genotoxicity of AEDs is still not fully understood. The aim of present study was to investigate the transplacental genotoxicity of valproate on animal model and in 21 mothers and their newborns receiving AED. In both studies, in vivo micronucleus (MN) assay was used. Pregnant dams were exposed to Na-valproate (100 mg/kg) on gestational days 12-14. Dams and pups receiving Na-valproate showed a significantly increased MN frequency (5.17±1.17/1000 ; 5.20±1.48/1000) compared to the control (1.0±0.58/1000 ; 1.67±1.03/1000). In mother/newborn study a significant increase of MN frequency was detected in newborns of mothers taking AEDs (3.09± 0.49/10 000) compared to the referent newborns (1.56 ±0.22/10 000). The results of this study suggest that AEDs may act as transplacental genotoxins. Launching the mother/newborn cohorts for genotoxicological monitoring may give a significant new insight in health effects of AEDs.

antiepileptic drug; genotoxicology; micronucleus assay; newborn; mouse; transplacental

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

30 (4)

2010.

613-618

objavljeno

0890-6238

10.1016/j.reprotox.2010.08.008

Povezanost rada

Temeljne medicinske znanosti, Kliničke medicinske znanosti

Poveznice
Indeksiranost