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Pregled bibliografske jedinice broj: 486719

Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+


Rajić, Zrinka; Zovko, Končić Marijana; Miloloža, Kristina; Perković, Ivana; Butula, Ivan; Bucar, Franz; Zorc, Branka
Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ // Acta pharmaceutica, 60 (2010), 3; 325-337 doi:10.2478/v10007-010-0024-9 (međunarodna recenzija, članak, znanstveni)


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Naslov
Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+

Autori
Rajić, Zrinka ; Zovko, Končić Marijana ; Miloloža, Kristina ; Perković, Ivana ; Butula, Ivan ; Bucar, Franz ; Zorc, Branka

Izvornik
Acta pharmaceutica (1330-0075) 60 (2010), 3; 325-337

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
primaquine ; NSAID ; twin drug ; conjugate ; radical scavenging ; antioxidant activity ; chelating ability

Sažetak
Novel primaquine conjugates with non-steroidal anti-inflammatory drugs (PQ-NSAIDs, 4a-h) were prepared, fully chemically characterized and screened for radical scavenging and antioxidant activities. The synthetic procedure leading to twin drugs 4a-h involved two steps: i) preparation of NSAID benzotriazolides 3a-h from the corresponding NSAID (ibuprofen, ketoprofen, fenoprofen, ketoprofen hydroxy and methylene analogues, diclofenac or indomethacin) and benzotriazole carboxylic acid chloride (BtCOCl, 1), ii) reaction of intermediates 3a-h with PQ. The prepared PQ-NSAIDs exerted moderate activities in the DPPH free radical test and b-carotene-linoleic acid assay. Moreover, ketoprofen derivatives 4d and 4b demonstrated a notable Fe2+ chelating ability as well. On the other hand, negligible antiproliferative and antituberculotic effects of conjugates 4a-h were observed.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
3917 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, MZOS)
3932 - Antioksidativni i prooksidativni učinak ljekovitih biljnih vrsta na hepatocite (Roberta Petlevski, MZOS)

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Citiraj ovu publikaciju

Rajić, Zrinka; Zovko, Končić Marijana; Miloloža, Kristina; Perković, Ivana; Butula, Ivan; Bucar, Franz; Zorc, Branka
Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+ // Acta pharmaceutica, 60 (2010), 3; 325-337 doi:10.2478/v10007-010-0024-9 (međunarodna recenzija, članak, znanstveni)
Rajić, Z., Zovko, K., Miloloža, K., Perković, I., Butula, I., Bucar, F. & Zorc, B. (2010) Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+. Acta pharmaceutica, 60 (3), 325-337 doi:10.2478/v10007-010-0024-9.
@article{article, year = {2010}, pages = {325-337}, DOI = {10.2478/v10007-010-0024-9}, keywords = {primaquine, NSAID, twin drug, conjugate, radical scavenging, antioxidant activity, chelating ability}, journal = {Acta pharmaceutica}, doi = {10.2478/v10007-010-0024-9}, volume = {60}, number = {3}, issn = {1330-0075}, title = {Primaquine-NSAID twin drugs: Synthesis, radical scavenging, antioxidant and Fe2+}, keyword = {primaquine, NSAID, twin drug, conjugate, radical scavenging, antioxidant activity, chelating ability} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • BIOSIS Previews (Biological Abstracts)
  • CA Search (Chemical Abstracts)
  • EMBASE (Excerpta Medica)
  • International Pharmaceutical Abstracts (IPA)
  • MEDLINE
  • BIOSIS Toxicology
  • Derwent Drug File
  • Journal Citation Reports/Science Edition


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