engleski

Antiaggregatory activity of flavonoids

Introduction: Antiaggregatory activity of flavonoids is well known property of these compounds. However, the results of a systematic search for highly potent members of this family are still missing. Moreover, different mechanisms of antiaggregatory action of this group of compounds were proposed. Material and methods: In order to analyze the antiaggregatory activity of series of flavonoids platelet impedance aggregation in whole blood has been selected while the ADP has been used as an aggregation agonist. For the analysis of possible mechanism of antiaggregatory action of the most potent compounds other aggregation agonists were also tested. Results: The following members among analyzed flavonoids show the most potent antiaggregatory effect: syringetin, 3, 6-dihydroxyflavone, rhamnethin. Besides inhibition of aggregation induced by ADP these compounds also inhibit the aggregation induced by collagen to some extent. Conclusions: Among the analyzed flavonoids the most potent members posses following structural properties: double bond on position C2-C3 and hydroxyl fgroup on position C3 of the ring C (flavonols). According to our results inhibition of phosphatidyl-inositol synthesis is the most likely explanation for antiaggregatory action throught interference with one or more common platelet signaling pathways.

antiaggregatory activity; flavonoids

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