Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease (CROSBI ID 166438)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Sell, David R. ; Nemet, Ina ; Monnier, Vincent M.
engleski
Partial characterization of the molecular nature of collagen-linked fluorescence : Role of diabetes and end-stage renal disease
Collagen-linked fluorescence at excitation/emission 370/440 nm has widely been used as a marker for advanced glycation in studies of aging, diabetic complications, and end-stage renal disease (ESRD). Diagnostic devices measuring skin autofluorescence at this wavelength revealed an association between fluorescence and cardiovascular morbidity and mortality. We now report the presence of a major fluorophore (LW-1) in human skin collagen which increases with age, diabetes, and ESRD. It has a molecular weight of 623.2 Da, a UV maximum at 348 nm, and involves a lysine residue in an aromatic ring. LW-1 could not be synthesized using traditional glycation chemistry suggesting a complex mechanism of formation, perhaps related to hypoxia since elevated levels were also found in nondiabetic individuals with chronic lung disease.
aging; glycation; skin; structure; marker; diabetes; renal disease
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Podaci o izdanju
493 (2)
2010.
192-206
objavljeno
0003-9861
10.1016/j.abb.2009.10.013