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Modelling of the bioconversion of glucose to 2,5-diketo-D-gluconic acid in continuous process

The process1 of bioconversion of glucose to 2,5-diketo-D-gluconic acid was performed in the continuous culture of Erwinia citreus (Pantoea citrea sp. nov.). On the basis of the experimental data the model for the continuous process was developed. The model parameters were estimated earlier by the oxygen partial pressure method2) and on the basis of dynamic responses method3). The developed model is compared with experimental data from batch and continuous culture experiment with Erwinia sp. for the series of initial glucose concentrations in the medium. A reasonable agreement was observed between the model simulations and the experimental data for the continuous culture growth on glucose as well as for the bioprocess products (gluconic acid, 2-keto-D-gluconic acid and 2,5-diketo-D-gluconic acid).

modelling of bioconversion; synthesis of 2;5-diketo-D-gluconic acid

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