engleski

Non-vertebrate animals have only one gene of the p53 family which is most similar to vertebrate p63

Genes of the p53 family are known to be critical regulators of the cell cycle. They have already been established as possible biomarkers. Elaborate regulation mechanisms result in numerous mRNA and protein isoforms being expressed from each gene of the family. A relatively recent discovery of p53 paralogs (p63 and p73) and high similarity of isoforms expressed from all three p53 family genes caused confusion in their nomenclature in non-vertebrate species. We analyzed all molluscan p53-similar sequences found in the GenBank database and compared their sequences and genomic structures to p53 family genes from other animals. Our results lead to the conclusion that invertebrates have only one gene of the p53 family which radiated into three genes only in vertebrates. This ancestral (molluscan) p53 family gene shows to be most similar to p63 in vertebrates. Furthermore, our analyses indicate p53 family genes to be single-copy genes thus increasing their value as potential biomarkers.

p53 family ; p63 ; mollusca ; Mytilus

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