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FUNCTIONALIZATION OF THE BENZOBICYCLO[3.2.1]OCTADIENE SKELETON


Škorić, Irena; Kikaš Ilijana, Šindler, Marija
FUNCTIONALIZATION OF THE BENZOBICYCLO[3.2.1]OCTADIENE SKELETON // 13th Ružička days, "Today science-tomorrow industry", Book of Abstracts / Šubarić, Drago (ur.).
Osijek, 2010. (predavanje, međunarodna recenzija, pp prezentacija, znanstveni)


Naslov
FUNCTIONALIZATION OF THE BENZOBICYCLO[3.2.1]OCTADIENE SKELETON

Autori
Škorić, Irena ; Kikaš Ilijana, Šindler, Marija

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, pp prezentacija, znanstveni

Izvornik
13th Ružička days, "Today science-tomorrow industry", Book of Abstracts / Šubarić, Drago - Osijek, 2010

Skup
13th Ružička days, "Today science-tomorrow industry"

Mjesto i datum
Vukovar, Hrvatska, 15-17.09.2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Benzobicyclo[3.2.1]octadiene; cycloadditions; functionalization; photochemistry

Sažetak
Many new rigid polycyclic structures 1-5 was obtained by photochemical cycloadditions of conjugated furan and butadiene systems in only one step, having benzobicyclo[3.2.1]octadiene skeleton.1 Exactly this skeleton represents the basic structural unit of the great number of important biologically active natural compounds.2 To achieve that objective, great intention was focused to the stereoselective formation of this structure3 and also to the determination of the relative stereochemistry on that bridged bicyclic system.4 Although the reactions of variously substituted bicyclo[3.2.1]octadiene structure has been thoroughly investigated, there is a need for new synthetic pathways concerning the biological activity of related functional derivatives. For that reason, various transformations were carried out on the benzobicyclic structures 1-5 obtained by photochemical methodology, 1 posessing furan ring or a double bond functionality for further transformations. Functionalization of this type of skeleton has been performed by oxidation and addition reactions to obtaine novel reactive and water-soluble derivatives. 1. I. Škorić, M. Šmehil, Ž. Marinić, K. Molčanov, B. Kojić-Prodić, M. Šindler-Kulyk, J. Photochem. Photobiol. A 207 (2009) 190–196 and references therein ; D. Vidaković, I. Škorić, M. Horvat, Ž. Marinić, M. Šindler-Kulyk, Tetrahedron 64 (2008) 3928–3934 ; I. Škorić, N. Basarić, Ž. Marinić, A. Višnjevac, B. Kojić-Prodić, M. Šindler-Kulyk, Chem. Eur. J. 11 (2005) 543–551. 2. L. N. Mander, Chem. Rev. 92 (1992) 573-612 ; H. Lin, S. J. Danishefsky, Angew. Chem. Int. Ed. 42 (2003) 36-51 ; H. Nagata, M. Kawamura, K. Ogasawara, Synthesis 13 (2000) 1825- 1834. 3. M.-H. Filippini, J. Rodriguez, Chem. Rev. 99 (1999) 27-76 ; P. Langer, E. Holtz, N. N. R. Saleh, Chem. Eur. J. 8 (2002) 917-928. 4. O. V. Patrusheva, G. A. Verbitskii, V. I. Vysotskii, Tetrahedron 60 (2004) 1761-1766.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
125-0982933-2926 - Heteropolicikli, strukturne osnove za bioaktivne spojeve. Sinteza i fotokemija (Irena Škorić, )

Ustanove
Fakultet kemijskog inženjerstva i tehnologije, Zagreb

Autor s matičnim brojem:
Irena Škorić, (235422)