engleski

The significance of routine immunological testing in following atopic dermatitis

The study comprised 100 examinees with atopic dermatitis and 50 examinees with chronic urticaria (adult patients and children) hospitalized or treated as outpatient in Allergy Unit, Department of Dermatovenereology, Zagreb Clinical Hospital, in the period from 1990 to 1994. The parameters for monitoring included a questionaire on personal and family atopic anamnesis and signs of atopy: laboratory findings, values of eosinophiles, total lymphocytes, T and B lymphocytes, serum immunoglobulin (IgG, IgA, IgM) total IgE antibodies and specific IgE antibodies, results of cutaneous tests:prick and intradermal tests to inhalative and nutritive allergens, scratch test to preservatives and additives, and epicutaneous (patch) to contact allergens. In detection and montoring of patients with atopic dermatitis, several methods were applied with different diagnostic success. From epidemiological data it was observed that there were more women than men among the patients, as well as more adult patients than children. Personal and family atopic anamnesis showed to be a useful indicator of the disease because in all patients with atopic dermatitis, atopic diathesis was found (probable, unclear, clear). Eosinophiles were mainly higher. The ELISA method, as well as RIST method, were useful in determination of IgE antibodies because their high values were found in the patients with atopic dermatitis. Of the applical skin tests, the most important was intradermal test which gave most of the positive results in the patients with atopic dermatitis (97.7%), then followed scratch test (83.3%), prick test (64.3%) and finally epicutaneous test (57.1%).

immunological testing; atopic dermatitis; chronic urticaria and atopic dermatitis

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