engleski

Prognostic Value of Nuclear Area in Intestinal Type of Gastric Cancer

Aim of this study was to evaluate the influence of nuclear area (morphometric method) on the survival of patients with intestinal type of gastric cancer. Seventy-four patients who had undergone gastric resections for adenocarcinoma of the stomach in the University Hospital Center of Rijeka, Croatia, were analyzed in this study. None had received pre-operative radiotherapy or chemotherapy. Age, gender, tumor size, TNM and nuclear area were estimated. All patients were followed up for at least 36 months or to death. Univariate analysis showed that gender (p=0.009), nuclear area (p=0.017), TNM (p=0.001) and size of the tumor (p=0.024) have influence on the survival. Patients age at the time of diagnosis showed no influence on the survival in univariate analysis (p=0.089). In multivariate analysis only TNM (p=0.048) and size of the tumor (p=0.020) are independent prognostic factors for planning further therapy. According to our results, reliable prognostic factors in patients with intestinal type of gastric cancer are still TNM and size of the tumor ; nuclear area showed no influence on the outcome of the disease.

gastric cancer ; nuclear area ; morphometric analysis ; survival

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