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Neuronal tryptophan hydroxylase (TPH2) in suicidal behaviour

Štefulj, Jasminka; Bordukalo-Nikšić, Tatjana
Neuronal tryptophan hydroxylase (TPH2) in suicidal behaviour // Translational Neuroscience, 1 (2010), 3; 207-213 doi:10.2478/v10134-010-0031-x (međunarodna recenzija, pregledni rad, znanstveni)

Neuronal tryptophan hydroxylase (TPH2) in suicidal behaviour

Štefulj, Jasminka ; Bordukalo-Nikšić, Tatjana

Translational Neuroscience (2081-3856) 1 (2010), 3; 207-213

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
Serotonin ; tryptophan hydroxylase ; gene ; polymorphism ; suicide

Serotonin (5-hydroxytryptamine, 5-HT) is a signalling molecule involved in many brain functions as well as in a variety of psychiatric conditions, including suicidal behaviour. Tryptophan hydroxylase (TPH), the rate-limiting enzyme of 5-HT biosynthesis, plays a critical role in 5-HT metabolism and thus in the regulation of 5-HT neurotransmission. There are two isoforms of TPH, so-called peripheral (TPH1) and neuronal (TPH2), encoded by the two distinct genes. TPH1 is abundant in the peripheral tissues, while TPH2 was detected exclusively within the nervous system. Since its discovery in 2003, TPH2 gene has attracted great interest as a potential factor contributing to diathesis of suicidal behaviour. However, initial positive findings indicating an association of TPH2 genetic variants with suicide have not been replicated consistently. Here we provide an overview of published studies to date, that have evaluated the contribution of TPH2 gene to the etiopathogenesis of suicidal behaviour.

Izvorni jezik

Znanstvena područja
Biologija, Temeljne medicinske znanosti


Projekt / tema
098-1081870-2395 - Serotonergična neurotransmisija: geni, proteini i ponašanje (Jasminka Štefulj, )

Institut "Ruđer Bošković", Zagreb

Časopis indeksira:

  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus