engleski

Cold haemagglutinin disease in two French bulldog pups - a case report

Cold haemagglutinin disease (CHD) was diagnosed in two newborn French bulldog pups. Necropsy revealed cyanosis and necrosis, formation of crusts on all anatomic extremities and amputation of lower parts of hind limbs. Histologically, on the limbs of both animals cutaneous necrosis with blood vessels thrombosis, hemorrhages and predominantly neutrophilic infiltration which affected periosteum of metatarsal bones were found. Surfaces of necrotic areas were covered with thick crusts with Gram positive bacterial colonies. In the spleen and liver erythrophagocytosis was present. Lung congestion, alveolar edema and thrombosis of pulmonary artery branches, cerebral and chorioidal vessels were present. Immunohistochemicaly, lymphocytes and plasma cells in necrotic tissue were positive for IgM. Bacteriological examination of swabs from necrotic areas revealed presence of Staphylococcus aureus. The diagnosis of CHD was based on macroscopic and histopathologic findings which were identical to those described in literature and was supported by immunohistochemical reactivity to IgM.

cold haemagglutinin disease; immune-mediated haemolytic anaemia; pathology; pup

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