engleski

Transcranial-duplex-Doppler US findings and neurodevelopmental outcome of infants with perinatal cerebral infarction

Objectives: We recorded cerebral flow velocities by TCDD in 10 infants diagnosed with cerebral infarction (CI) of the irrigational area of the middle cerebral artery (MCA), with special reference to the etiology and pathogenesis of CI. We correlated the hemispheral localization and the distribution of the lesion with neurodevelopmental outcome of the children affected. Patients and methodes: Two children were preterms and other eight were full terms. The diagnosis was obtained in all children by using cranial US, CT and MRI. Because of vascular etiology of lesion cerebral circulation was investigated by TCDD. Perinatal risk factors were assessed and patients underwent neurodevelopmental follow-up for 1-14 years. Results: Cerebral infarction involved the irrigational area of MCA. Asymmetric flow between the left and right MCA was the main finding on the TCDD. Lower velocities were found in the MCA on the affected side. These side-to-side differences were present at subsequent Doppler measurements. The lesion was more often found on the left side. The distributin of the was classified as the area of the lesion determines the neurological sequels. All infants had impaired psychomotoric development: contralateral hemiparesis, persistant seizures and languagedevelopment delay. The level of cognitive functioning was variable. Conclusions: Based on clinical and diagnostical follow-up the results showed no simple and clear connection between lesion parameters and neurodevelopmental outcome. We suppose that the time when lesion occurred is crucial for the possible neurodevelopmental outcome. The data indicates that beside brain US, CT and MR, TCDD can be useful method for identifying infants with suspected cerebral infarction.

nije evidentirano

nije evidentirano