engleski

Clinical Value of C-reactive Protein and Elastase in Assessment of Acute Pancreatitis

The early prognostic evaluation of acute pancreatitis (AP) is a key step in appropriatemanagement of the disease. The aim of the study was to evaluate the serum levels of CRP and elastase (E) as early prognostic markers in a development of severe acute pancreatitis. Elastase were analyzed by ELISA method and CRP by immunoturbidimetry in serum taken routinely from 150 patients with acute pancreatitis on the first and on the third day of admission. APACHE II score was calculated on admission. Systemic complications were classified according to the Atlanta crite-ria. Severe acute pancreatitis developed in 19% of patients. Serum levels of CRP and elastase on the first day of admission were not significantly different in patients without and those with complications of acute pancreatitis (14.4 vs 15mg/L ; p = 0.954 and 5.7 vs 7.5ng/L ; p = 0.249), but on the third day of admission, the serum levels of CRP and elastase were significantly higher in the group of patients with complications (85 vs 216 mg/L ; p = 0.002 and 1.7 vs 2.5 ng/L ; p = 0.001). The area under the curve (AUC) for CRP on the third day was 0.69, at a cut-off value of 214 mg/L and for elastase 0.70 at a cut-off value of 1.5 ng/L. CRP levels were higher, and elastase levels were lower on the third day compared to the first day after admission. Quantification of CRP and elastase on the third day of admission seems to be an accurate method in the prognostic evaluation of acute pancreatitis.

CRP; elastase; acute pancreatitis

doi: 10.1159/000314328