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Clinical Value of C-reactive Protein and Elastase in Assessment of Acute Pancreatitis


Štimac, Davor; Fišić, Elizabeta; Bilić-Zulle, Lidija; Krznarić-Zrnić, Irena; Milić, Sandra
Clinical Value of C-reactive Protein and Elastase in Assessment of Acute Pancreatitis // Abstracts 42nd European Pancreatic Club (EPC) Meeting ; u: Pancreatology 10 (2010) (2/39 ; P61
Basel: Karger, 2010. str. 347-347 (poster, međunarodna recenzija, sažetak, znanstveni)


Naslov
Clinical Value of C-reactive Protein and Elastase in Assessment of Acute Pancreatitis

Autori
Štimac, Davor ; Fišić, Elizabeta ; Bilić-Zulle, Lidija ; Krznarić-Zrnić, Irena ; Milić, Sandra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts 42nd European Pancreatic Club (EPC) Meeting ; u: Pancreatology 10 (2010) (2/39 ; P61 / - Basel : Karger, 2010, 347-347

Skup
42nd European Pancreatic Club Meeting (42 ; 2010)

Mjesto i datum
Stockholm, Švedska, 17.-19.06.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CRP; elastase; acute pancreatitis

Sažetak
The early prognostic evaluation of acute pancreatitis (AP) is a key step in appropriatemanagement of the disease. The aim of the study was to evaluate the serum levels of CRP and elastase (E) as early prognostic markers in a development of severe acute pancreatitis. Elastase were analyzed by ELISA method and CRP by immunoturbidimetry in serum taken routinely from 150 patients with acute pancreatitis on the first and on the third day of admission. APACHE II score was calculated on admission. Systemic complications were classified according to the Atlanta crite-ria. Severe acute pancreatitis developed in 19% of patients. Serum levels of CRP and elastase on the first day of admission were not significantly different in patients without and those with complications of acute pancreatitis (14.4 vs 15mg/L ; p = 0.954 and 5.7 vs 7.5ng/L ; p = 0.249), but on the third day of admission, the serum levels of CRP and elastase were significantly higher in the group of patients with complications (85 vs 216 mg/L ; p = 0.002 and 1.7 vs 2.5 ng/L ; p = 0.001). The area under the curve (AUC) for CRP on the third day was 0.69, at a cut-off value of 214 mg/L and for elastase 0.70 at a cut-off value of 1.5 ng/L. CRP levels were higher, and elastase levels were lower on the third day compared to the first day after admission. Quantification of CRP and elastase on the third day of admission seems to be an accurate method in the prognostic evaluation of acute pancreatitis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

Napomena
Doi: 10.1159/000314328



POVEZANOST RADA


Projekt / tema
062-0000000-0211 - Učinci enteralne prehrane u teškom akutnom pankreatitisu (Davor Štimac, )

Ustanove
Medicinski fakultet, Rijeka,
Klinički bolnički centar Rijeka

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE