engleski

Soluble TNF Alpha Receptor (sTNF Alpha R) is an Important Marker of Severe Acute Pancreatitis

Acute pancreatitis is inflammatory process, usually limited to pancreas. Systemic involvement of distant organs defines severe form of the disease (severe acute pancreatitis – SAP) that leads to multiple organ failure and death ultimately. It is very important to predict the course in the early stage of the disease. Some cytokines (IL-6, IL-8) are good markers for prediction of SAP. Objectives were to establish the prognostic value of sTNFαR as new potential marker for development of severe acute pancreatitis. The study was carried out in a group of 150 patients with acute pancreatitis (71 males, 79 females) admit-ted to our Division of Gastroenterology. Concentration of sTNFR was determined by enzyme-linked immunosorbent assay (ELISA) from the blood samples taken on the admission day. Prognostic value of sTNFR was performed by ROC analysis. sTNFR showed high sensitivity (82%) for predicting development of SAP at cut off value of 1552 pg/mL. Specificity was 65% (AUC 0.69, CI 0.60-0.76). IL-6 and IL-8 showed also high prog-nostic values (AUC 0.71 95% CI 0.63-0.78 and AUC 0.66 95% CI 0.58-0.74). Our results have shown that sTNFR could be a very useful early prognostic marker for development of severe acute pancreatitis.

TNF-alfa; acute pnacreatitis; prognosis

DOI: 10.1159/000314328 ; Rad je kao predavanje porezentiran na skupu 11th European bridging meeting in gastroenterology, održanom od 31.11.-01.12.2009., Beograd, Srbija ; objavljen u Knjizi sažetaka , str. 24-24.