engleski

Red Distribution Width (RDW) and Ferritin as Prognostic Factors in Acute Pancreatitis

Introduction: RDW is a standard parameter of complete blood count. The usefulness of determining the value of RDW examined in many pathological inflammatory and non-inflammatory conditions such as inflammatory bowel diseases, myocardial infarction, heart failure, renal failure, but not in acute pancreatitis (AP). Ferritin is an acute phase reactant and thus may be increased in patients with inflammation, like AP, and also in liver disease, chronic infection, autoimmune disorders, and some types of cancer. Ferritin is not typically used to detect or monitor these conditions. Objectives: To determine correlation of RDW and ferritin with the clinically used predictors of severity of acute pancreatitis such as complex scoring systems (Ranson and APACHE II). Patients and Methods: One hundred and forty-one patients (52%male and 48% female) in a 2-year period (2007-2008) were enrolled in this study. RDW and ferritin values were obtained on an automated hematology analyzer (Olympus AU 640, Tokio, Japan). Statistical methods used Pearson’s correlation test. Results: RDW showed moderate correlation to Ranson (r = 0.201, p = 0.017) and moderate correlation to APACHE II (r = 0.256, p = 0.002) as a marker for predicting severity of AP. There was neither significant correlation between ferritin and Ranson (r = 0.007, p = 0.932), as well as Appache II scores (r = 0.070, p = 0.414). Conclusion: To our knowledge, our study demonstrates for the first time that RDW is inexpensive, easily obtained, and powerful prognostic marker for AP, but warrants furtherconfirming studies in larger series of patients.

RDW; ferritin; prognosis; acute pancreatitis

DOI: 10.1159/000314328 ; Rad je kao poster prezentiran i na skupu 18th UEGW, odrzžanom od 23.-27.10.2010.g., Barcelona, Španjolska ; uz međunarodnu recenziju objavljen u Knjizi sažetaka u sklopu CC-casopisu Gut.