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Pregled bibliografske jedinice broj: 476895

Novel Ureidoamides Derived from Amino Acids: Synthesis and Preliminary Biological Screening


Perković, Ivana; Butula, Ivan; Rajić, Zrinka; Hadjipavlou-Litina, Dimitra; Pontiki, Eleni; Zorc, Branka
Novel Ureidoamides Derived from Amino Acids: Synthesis and Preliminary Biological Screening // Croatica chemica acta, 83 (2010), 2; 151-161 (međunarodna recenzija, članak, znanstveni)


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Naslov
Novel Ureidoamides Derived from Amino Acids: Synthesis and Preliminary Biological Screening

Autori
Perković, Ivana ; Butula, Ivan ; Rajić, Zrinka ; Hadjipavlou-Litina, Dimitra ; Pontiki, Eleni ; Zorc, Branka

Izvornik
Croatica chemica acta (0011-1643) 83 (2010), 2; 151-161

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
urea; amide; amino acid; benzotriazole; hydantoin; hydroxylamine; antioxidant activity

Sažetak
A series of novel amino acid ureidoamides 4a-o were prepared from N-(1-benzotriazolecarbonyl)- amino acid chloride 3, derived from L-alanine, L-valine, L-leucine, D-phenylglycine and L-phenylalanine, and the corresponding aminoalcohols (2-amino-1-ethanol, 3-amino-1-propanol and 5-amino-1-pentanol). The compounds were fully characterized by standard spectroscopic methods (IR, 1H and 13C NMR) and their structure was confirmed by elemental analysis. Antioxidant screenings (interaction with 1, 1-diphenyl-2-picrylhydrazyl, soybean lipoxygenase inhibition activity, inhibition of linoleic acid lipid peroxidation) revealed that the prepared compounds possessed only modest activity. On the other hand, no significant antiproliferative activity against five human cell lines and very weak antimicrobial activity against several bacteria and fungi were detected.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija



POVEZANOST RADA


Projekt / tema
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb

Profili:

Avatar Url Ivan Butula (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Ivana Perković (autor)

Avatar Url Branka Zorc (autor)

Citiraj ovu publikaciju

Perković, Ivana; Butula, Ivan; Rajić, Zrinka; Hadjipavlou-Litina, Dimitra; Pontiki, Eleni; Zorc, Branka
Novel Ureidoamides Derived from Amino Acids: Synthesis and Preliminary Biological Screening // Croatica chemica acta, 83 (2010), 2; 151-161 (međunarodna recenzija, članak, znanstveni)
Perković, I., Butula, I., Rajić, Z., Hadjipavlou-Litina, D., Pontiki, E. & Zorc, B. (2010) Novel Ureidoamides Derived from Amino Acids: Synthesis and Preliminary Biological Screening. Croatica chemica acta, 83 (2), 151-161.
@article{article, year = {2010}, pages = {151-161}, keywords = {urea, amide, amino acid, benzotriazole, hydantoin, hydroxylamine, antioxidant activity}, journal = {Croatica chemica acta}, volume = {83}, number = {2}, issn = {0011-1643}, title = {Novel Ureidoamides Derived from Amino Acids: Synthesis and Preliminary Biological Screening}, keyword = {urea, amide, amino acid, benzotriazole, hydantoin, hydroxylamine, antioxidant activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Uključenost u ostale bibliografske baze podataka:


  • CA Search (Chemical Abstracts)
  • Scopus
  • Cambridge Structural Database System
  • Directory of Open Access Journals





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