engleski

In vitro cultivation of porcine limbal transplant

The stem cells, providing tissue regeneration are residents of different organ structures in the body and are usually located in well protected sites of organs and tissues. For stem cells of either corneal epithelium such sites are in the basal epithelial layer of cornea residing its limbal region termed palisade of Voight. A growing interest in allografts and xenografts implies a thorough study of regenerative potentials of these cells as well as a clear description of their patterns in the in vitro tissue cultures to be grafted. The aim of this study was to evaluate the culturing patterns of porcine limbal stem cells and to optimize growing conditions of these cell cultures in order to develop a reliable biomedical model intended for studying the potentials of allografts/xenografts originated from porcine tissues.. Porcine stem cell equivalents have potentials in reparative/regenerative veterinary medicine of pets, horses and selected breeds of food animals, but also as xenografts for humans.

stem cells; cornea; porcine

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