Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 473893

Asynchronous replication of human subtelomeric regions


Petković, Iskra
Asynchronous replication of human subtelomeric regions // European Journal of Human Genetics / G.-J.B. van Ommen (ur.).
London, UK: Nature publishing group, 2010. str. 124-124 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 473893 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Asynchronous replication of human subtelomeric regions

Autori
Petković, Iskra

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of Human Genetics / G.-J.B. van Ommen - London, UK : Nature publishing group, 2010, 124-124

Skup
European Human Genetics Conference 2010

Mjesto i datum
Gothenburg, Sweden, 12-15. 06. 2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
replication timing; subtelomeric region; human

Sažetak
Replication of human genome is linked to different basic cellular processes. Studies conducted so far have shown that timing of DNA replication correlates with genomic instability, transcriptional activity, gene density and chromatin structure. Synchronous replication of alleles was demonstrated for genes with a biallelic expression while asynchronous replication for those with monoallelic mode of expression due to imprinting, X-inactivation or allelic exclusion. Little is known about replication timing(RT) of subtelomeric regions(SR), and its correlation with chromatin structure and function remains poorly understood. SRs of human chromosomes are highly unstable, rich in genes and frequently involved in aberrations and thus are of particular clinical interest. In this study the replication pattern of SR of chromosomes 2, 5, 7, 8, 9, 16, 19 and 20 was investigated using FISH method in lymphocytes of 8 healthy donors. At least 200 cells/probe/person were analyzed. The replication status of a locus was classified as unreplicated(s) and replicated(d). The analysis revealed marked heterogeneity of investigated SR. The data suggested a continuum of replication throughout S phase, with SR9p (dd:20.9±0.96%) being the first, and SR2p (dd:3.7±0.51%) the last to replicate (p<0.01). The results showed asynchronous replication at some SR. The frequency of sd ranged from 18.6% to 33.2% and the mean for SR19q2q16q20q5p (sd:31.08±0.52%) was significantly higher (p<0.01) compared to SR2p7q5q (sd:19.9±0.58%). This investigation revealed that different SR replicates at different times during S phase and that certain homologous loci replicate asynchronously. Although the significance of RT is unclear yet, it might contribute to the non-random involvement of specific SR in chromosomal rearrangements.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
072-1083107-0361 - Telomere i kromosomske aberacije u patologiji dječje dobi (Petković, Iskra, MZOS - )

Ustanove
Klinika za dječje bolesti Medicinskog fakulteta

Profili:

Avatar Url Iskra Petković (autor)

Citiraj ovu publikaciju

Petković, Iskra
Asynchronous replication of human subtelomeric regions // European Journal of Human Genetics / G.-J.B. van Ommen (ur.).
London, UK: Nature publishing group, 2010. str. 124-124 (poster, međunarodna recenzija, sažetak, znanstveni)
Petković, I. (2010) Asynchronous replication of human subtelomeric regions. U: G.-J.B. van Ommen (ur.)European Journal of Human Genetics.
@article{article, author = {Petkovi\'{c}, I.}, year = {2010}, pages = {124-124}, keywords = {replication timing, subtelomeric region, human}, title = {Asynchronous replication of human subtelomeric regions}, keyword = {replication timing, subtelomeric region, human}, publisher = {Nature publishing group}, publisherplace = {Gothenburg, Sweden} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font