engleski

Effects of IV lidocaine administered prior to extubation on early and late recovery after breast surgery

Systemic lidocaine may suppress tracheal tube induced coughing and postoperative sore throat (1). Data about the influence of IV lidocaine given immediately before extubation are sparse. We investigated in prospective, randomized, double‐blind study whether IV lidocaine administered prior to extubation has influence on emergence and recovery after general anesthesia in women undergone breast surgery. After obtaining IRB approval and informed consents, 48 women, ASA PS I‐II, scheduled for breast surgery were randomized to receive IV lidocaine bolus of 1.5 mg/kg (GL group, n=25) or saline placebo (GS group, n=23) at the end of anesthesia, when sevoflurane was discontinued. Anesthesia was standardized (sevoflurane 1 MAC in 50% N2O and oxygen). Early recovery, PONV/pain scores, cough and sore throat during 24 hours were recorded by a blinded anesthesiologist. Diclofenac and meperidine were given for pain and metoclopramide for PONV. Data, mean (SD) or n (%), were analyzed using χ2 and t test. GL group was similar to GS group regarding age, BMI, ASA PS status, anesthesia time and PONV risk score. Recovery data are presented in Table 1. There was no difference in pain scores or the opioid consumption. Administration of IV lidocaine at the end of anesthesia attenuated strain and cough on extubation and sore throat during first 24 hours after general anesthesia after breast surgery without prolonging the emergence. Lidocaine did not influence postoperative pain and the incidence of PONV. IV lidocaine prior to extubation may be useful in surgeries when straining and coughing on emergence increase postoperative complications.

lidocaine; early and late recovery; strain; sore throat

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