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Phenanthridinium cyclobisintercalands. Fluorescence sensing of AMP and selective binding to single-stranded nucleic acids


Piantanida, Ivo; Palm, Barbara Susanne; Čudić, Predrag; Žinić, Mladen; Schneider, Hans-Joerg
Phenanthridinium cyclobisintercalands. Fluorescence sensing of AMP and selective binding to single-stranded nucleic acids // Tetrahedron Letters, 42 (2001), 6779-6783 (međunarodna recenzija, članak, znanstveni)


Naslov
Phenanthridinium cyclobisintercalands. Fluorescence sensing of AMP and selective binding to single-stranded nucleic acids

Autori
Piantanida, Ivo ; Palm, Barbara Susanne ; Čudić, Predrag ; Žinić, Mladen ; Schneider, Hans-Joerg

Izvornik
Tetrahedron Letters (0040-4039) 42 (2001); 6779-6783

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Phenanthridinium; receptor; cyclobisintercaland; nucleic acid

Sažetak
Macrocyclic ligands 1 and 2 containing two positively charged phenanthridinium units and aminobisacetylenic bridges, exhibit significantly higher affinity toward singlestranded than doublestranded polynucleotides. The ligands bis-intercalate into the former and show non-intercalative interactions with the latter type of nucleic acids. Both ligands differentiate AMP from the GMP or UMP by significant fluorescence emission increase upon complexation of the first nucleotide in water (log Ks of 1:1 and 1:2 complexes 5.8 and 1.4, respectively) while only slight emission change is observed in titrations with GMP and UMP.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
00980703

Ustanove
Institut "Ruđer Bošković", Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus