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Pregled bibliografske jedinice broj: 471970

One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate


Majerić Elenkov, Maja; Tang, Lixia; Hauer, Bernhard; Janssen, Dick B.
One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate // Practical Methods for Biocatalysis and BIotransformations / Whittall, John ; Sutton, Peter (ur.).
Weinheim: John Wiley & Sons, 2009. str. 199-202


Naslov
One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate

Autori
Majerić Elenkov, Maja ; Tang, Lixia ; Hauer, Bernhard ; Janssen, Dick B.

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, ostalo

Knjiga
Practical Methods for Biocatalysis and BIotransformations

Urednik/ci
Whittall, John ; Sutton, Peter

Izdavač
John Wiley & Sons

Grad
Weinheim

Godina
2009

Raspon stranica
199-202

ISBN
978-0-470-51927-1

Ključne riječi
biocatalysis, halohydrin dehalogenase, epoxide

Sažetak
The kinetic resolution of methyl 4-chloro-3-hydroxybutanoate by enantioselective epoxide ring opening with cyanide and a mutant halohydrin dehalogenase1 afforded two versatile building blocks in highly enantioenriched form (>95 % ee) and in high yield (81 % total yield). The transformation of halohydrin to cyanohydrin proceeds via an epoxide intermediate that is transiently present in low amount during the reaction. This is an example of a sequential kinetic resolution in which two steps are catalysed by a single halohydrin dehalogenase.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekt / tema
098-0982933-2908 - Kiralni građevni blokovi za biološki aktivne molekule. Sinteza i reaktivnost (Zdenko Hameršak, )

Ustanove
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Maja Majerić-Elenkov (autor)

Citiraj ovu publikaciju

Majerić Elenkov, Maja; Tang, Lixia; Hauer, Bernhard; Janssen, Dick B.
One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate // Practical Methods for Biocatalysis and BIotransformations / Whittall, John ; Sutton, Peter (ur.).
Weinheim: John Wiley & Sons, 2009. str. 199-202
Majerić Elenkov, M., Tang, L., Hauer, B. & Janssen, D. (2009) One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate. U: Whittall, J. & Sutton, P. (ur.) Practical Methods for Biocatalysis and BIotransformations. Weinheim, John Wiley & Sons, str. 199-202.
@inbook{inbook, year = {2009}, pages = {199-202}, keywords = {biocatalysis, halohydrin dehalogenase, epoxide}, isbn = {978-0-470-51927-1}, title = {One-pot Biocatalytic Synthesis of (S)-4-Chloro-3-hydroxybutanoate and Methyl (S)-Cyano-3-hydroxybutanoate}, keyword = {biocatalysis, halohydrin dehalogenase, epoxide}, publisher = {John Wiley and Sons}, publisherplace = {Weinheim} }