Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity (CROSBI ID 164208)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Hutinec, Antun ; Ðerek, Marko ; Lazarevski, Gorjana ; Šunjić, Vitomir ; Čipčić Paljetak, Hana ; Alihodžoć, Sulejman ; Eraković Haber, Vesna ; Dumić, Miljenko ; Maršić, Nataša ; Mutak, Stjepan
engleski
Novel 8a-aza-8a-homoerythromycin—400-(3- substituted-amino)propionates with broad spectrum antibacterial activity
Fifteen-membered 8a-aza-8a-homoerythromycins derived from either erythromycin or clarithromycin have been acylated to form 400-O-propenoyl derivative. These functionalized analogues underwent Michael reaction with primary or secondary amines to afford novel 8a-aza-8a- homoerythromycin—400- (3-substituted- amino)propionates. This preparative sequence was adapted so that analogues could be made by parallel synthesis. Among them, 4-quinolone derivatives show particularly good antibacterial potency against macrolide resistant bacteria, comparable or better than azithromycin and telithromycin.
macrolide; azalide; 8a-aza-8a-Homoerythromycin—400-(3-substituted-amino)propionates; antibacterial activity; rResistance
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Podaci o izdanju
20 (11)
2010.
3244-3249
objavljeno
0960-894X
10.1016/j.bmcl.2010.04.062
Povezanost rada
Temeljne medicinske znanosti