engleski

Repeated thyroid FNAs

Aim: To investigate possible changes of primary FNA diagnoses after subsequent check up’s. Methods: During an eight year period (2001-2009) we investigated possible changes of primary FNA diagnoses of 948 nodules. The main indications for repeated FNAs were inadequate/indeterminate FNA findings, and growing nodules at ultrasound check up. FNA findings were subdivided in 6 categories: inadequate, benign, low-risk lesion (includes cellular follicular lesion, suspicious of follicular/Hürthle cell neoplasm, atypical Hürthle cell hyperplasia), suspicious (includes follicular/Hürthle cell neoplasm), high-risk lesion (includes lesions suspicious of malignancy, i.e. suspicious of papillary carcinoma), and malignant lesions. The relapsed time between two subsequent FNAs varied from 1 to 109 months (median 14 months). Results: Of the total of 948 nodules, repeated FNA diagnoses remained within the same category in 709 (75%) nodules. Out of 38 primary inadequate FNAs, 7 (18%) remained inadequate, 24 (63%) were benign, and 3 (8%) were categorized as high-risk/malignant lesions. Out of 659 primary benign FNAs 586 (89%) remained benign, and 11 (2%) were categorized as high-risk/malignant lesions. Out of 169 primary low-risk lesions FNAs, 66 (39%) remained low-risk, 65 (38%) were benign, and 10 (6%) were categorized as high-risk/malignant lesions. Out of 43 primary high-risk lesions FNAs, 20 (46%) remained high-risk, 2 (5%) were benign, 3 (7%) were categorized as a low-risk lesion, and 13 (30%) were categorized as malignant. Out of 35 FNAs that were primary suspicious of follicular/Hürthle cell neoplasm, 27 (77%) remained suspicious of follicular/Hürthle cell neoplasm, 1 (3%) was categorized as benign, 4 (11%) were categorized as a low-risk lesion, and 3 (8%) were categorized as high-risk/malignant lesions. Conclusion: Our results show that repeated thyroid FNA is useful in most cases of primary inadequate/indeterminate FNA findings, as well as in the evaluation of growing nodules.

cytology; thyroid

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