Functional plasticity and robustness are essential characteristics of biological systems : lessons learned from KLRG1-deficient mice (CROSBI ID 164127)
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Jonjić, Stipan
engleski
Functional plasticity and robustness are essential characteristics of biological systems : lessons learned from KLRG1-deficient mice
Killer cell lectin-like receptor G1 (KLRG1) receptor is considered to be a marker of terminally differentiated NK and T cells and is strongly induced by viral and other infections. KLRG1 is a C-type lectin-like inhibitory receptor, which interacts with members of the cadherin family of molecules leading to the inhibition of T- and NK-cell function. A study in this issue of the European Journal of Immunology addresses the role of KLRG1 in the maturation and differentiation of NK and T cells in vivo. Using KLRG1-deficient mice generated by homologous recombination, the study reveals that KLRG1 is dispensable for NK- and CD8+ T-cell differentiation and function in vivo. This interesting finding is discussed in this Commentary in light of the plasticity and robustness of immune response mechanisms
KLRG1 deficient mice; NK cells; T cells
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