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N-Sulfonylpyrimidine derivatives and hyperthermia treatment of anaplastic mammary carcinoma in vivo

The aim of this study was to investigate in vivo antitumor activity of newly synthesized N-sulfonylpyrimidine derivatives applied as a single agent and in combination with hyperthermia (43 oC/60 min). Antitumor activity was examined for: 1-(p-toluenesulfonyl)cytosine (4H), 1-(p-toluenesulfonyl)cytosine hydrochloride (4HxHCl), complex (Zn(II) [1-(p-toluenesulfonyl)cytosine]2) (4K) and 5-bromo-1-(methanesulfonyl)uracil (8H). In the study was used transplantable anaplastic mammary carcinoma (AMCa). All experiments were performed on 10-14-week-old female CBA mice weighting 22-25 g at the time of treatment. The obtained data show that N-sulfonylpyrimidine derivatives (4H, 4HxHCl, 4K, 8H) posses antitumor activity. In combination with hyperthermia, the highest enhancement was obtained when hyperthermia was applied with 4HxHCl (300 mg/kg). The antitumor activity of N-sulfonylpyrimidine derivatives was similar or better than antitumor effect of 5-fluorouracil (positive control). These findings give a good reason for further research of these compounds both in experimental and preclinical studies.

hyperthermia; mammary carcinoma; mice; N-sulfonylpyrimidine derivatives

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