engleski

Tissue-infiltrating lymphocytes in psoriasis vulgaris lesions express TRAIL and its receptors DR4 and DR5

Aim: To investigate the expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) and its two death receptors DR4 and DR5 in psoriasis vulgaris lesions and to characterize the pattern of their expression among cell subsets of the psoriatic dermal infiltrate. Methods: Immunohistochemistry was performed on normal skin (n=5) as well as lesional (n=5) and non-lesional (n=5) skin of patients with plaque psoriasis. Co-localization of TRAIL, DR4 and DR5 with cell markers of different lymphocyte subsets (CD4, CD8, CD56) was performed by double immunofluorescence staining. Results: The expression of TRAIL and its receptors was found to be significantly enhanced in the dermis of lesional psoriatic skin as compared to non-lesional and normal skin. Immunoreactivity for each of the examined proteins was readily detected in CD4+ and CD8+ and some CD56+ cells. Conclusion: TRAIL and its receptors DR4 and DR5 are highly expressed among cells of the dermal infiltrate in psoriasis vulgaris lesions. These findings suggest a significant contribution of TRAIL signalling system in the inflammatory cascade involved in the pathogenesis of this skin disease.

psoriasis; TRAIL; DR4; DR5

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