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Pregled bibliografske jedinice broj: 470693

The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents


Rajić, Zrinka; Hadjipavlou-Litina, Dimitra; Pontiki, Eleni; Kralj, Marijeta; Šuman, Lidija; Zorc, Branka
The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents // Chemical biology & drug design, 75 (2010), 641-652 doi:10.1111/j.1747-0285.2010.00963.x (međunarodna recenzija, članak, znanstveni)


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Naslov
The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents

Autori
Rajić, Zrinka ; Hadjipavlou-Litina, Dimitra ; Pontiki, Eleni ; Kralj, Marijeta ; Šuman, Lidija ; Zorc, Branka

Izvornik
Chemical biology & drug design (1747-0277) 75 (2010); 641-652

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
ketoprofen derivatives; amide; soybean lipoxygenase; antioxidant activity; cytostatic activity

Sažetak
The novel amides of ketoprofen and its reduced derivatives (5a-f, 4a-n, 6a-g) with aromatic and cycloalkyl amines or hydroxylamines were prepared and screened for their reducing and cytostatic activity as well as for their ability to inhibit soybean lipoxygenase and lipid peroxidation. DPPH test for reducing ability revealed that ketoprofen amides were more potent antioxidants than the amides of the reduced ketoprofen derivatives. The most active compound was benzhydryl ketoprofen amide 5f. Lipoxygenase inhibition of the tested compounds varied from strong to very weak. The most potent compound was benzhydryl derivative 6f (IC50 = 20.5 μM). Aromatic and cycloalkyl amides 4 and 5 were more potent lipoxygenase inhibitors than derivatives with carboxylic group. Aromatic amides of series 4 and 5 showed excellent lipid peroxidation inhibition (92.299.9%). On the other hand, the most pronounced cytostatic activity was exerted by O-benzyl derivative 4i, although in general all tested reduced and nonreduced lipophilic derivatives showed similar activity.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Farmacija



POVEZANOST RADA


Projekt / tema
098-0982464-2514 - Uloga različitih mehanizama odgovora stanica na terapiju oštećenjem DNA (Marijeta Kralj, )
006-0000000-3216 - Sinteza, karakterizacija i djelovanje potencijalnih i poznatih ljekovitih tvari (Branka Zorc, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb

Profili:

Avatar Url Marijeta Kralj (autor)

Avatar Url Zrinka Rajić (autor)

Avatar Url Lidija Šuman (autor)

Avatar Url Branka Zorc (autor)

Citiraj ovu publikaciju

Rajić, Zrinka; Hadjipavlou-Litina, Dimitra; Pontiki, Eleni; Kralj, Marijeta; Šuman, Lidija; Zorc, Branka
The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents // Chemical biology & drug design, 75 (2010), 641-652 doi:10.1111/j.1747-0285.2010.00963.x (međunarodna recenzija, članak, znanstveni)
Rajić, Z., Hadjipavlou-Litina, D., Pontiki, E., Kralj, M., Šuman, L. & Zorc, B. (2010) The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents. Chemical biology & drug design, 75, 641-652 doi:10.1111/j.1747-0285.2010.00963.x.
@article{article, year = {2010}, pages = {641-652}, DOI = {10.1111/j.1747-0285.2010.00963.x}, keywords = {ketoprofen derivatives, amide, soybean lipoxygenase, antioxidant activity, cytostatic activity}, journal = {Chemical biology and drug design}, doi = {10.1111/j.1747-0285.2010.00963.x}, volume = {75}, issn = {1747-0277}, title = {The Novel Ketoprofen Amides – Synthesis and Biological Evaluation as Antioxidants, Lipoxygenase Inhibitors and Cytostatic Agents}, keyword = {ketoprofen derivatives, amide, soybean lipoxygenase, antioxidant activity, cytostatic activity} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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