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Pregled bibliografske jedinice broj: 470391

Meta-analysis and imputation refines the association of 15q25 with smoking quantity


Liu, Jason Z.; ...; Polašek, Ozren; Zgaga, Lina; ...; Rudan, Igor; ...; Kolčić, Ivana; ...; Marchini, Jonathan
Meta-analysis and imputation refines the association of 15q25 with smoking quantity // Nature genetics, 42 (2010), 5; 436-440 doi:10.1038/ng.572 (međunarodna recenzija, članak, znanstveni)


Naslov
Meta-analysis and imputation refines the association of 15q25 with smoking quantity

Autori
Liu, Jason Z. ; ... ; Polašek, Ozren ; Zgaga, Lina ; ... ; Rudan, Igor ; ... ; Kolčić, Ivana ; ... ; Marchini, Jonathan

Izvornik
Nature genetics (1061-4036) 42 (2010), 5; 436-440

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Genome-wide association study; smoking initiation; smoking quantity

Sažetak
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41, 150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Ustanove
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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