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New loci associated with kidney function and chronic kidney disease


Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V. et al.
New loci associated with kidney function and chronic kidney disease // Nature genetics, 42 (2010), 5; 376-384 doi:10.1038/ng.568 (međunarodna recenzija, članak, znanstveni)


Naslov
New loci associated with kidney function and chronic kidney disease

Autori
Köttgen, A. ; Pattaro, C. ; Böger, C.A. ; Fuchsberger, C. ; Olden, M. ; Glazer, N.L. ; Parsa, A. ; Gao, X. ; Yang, Q. ; Smith, A.V. ; O'Connell, J.R. ; Li, M. ; Schmidt, H. ; Tanaka, T. ; Isaacs, A. ; Ketkar, S. ; Hwang, S.J. ; Johnson, A.D. ; Dehghan, A. ; Teumer, A. ; Paré, G. ; Atkinson, E.J. ; Zeller, T. ; Lohman, K. ; Cornelis, M.C. ; Probst-Hensch, N.M, ; Kronenberg, F. ; Tönjes, A. ; Hayward, C. ; Aspelund, T. ; Eiriksdottir, G. ; Launer, L.J. ; Harris, T.B. ; Rampersaud, E. ; Mitchell, B.D. ; Arking, D.E. ; Boerwinkle, E. ; Struchalin, M. ; Cavalieri, M. ; Singleton, A. ; Giallauria, F. ; Metter, J. ; de Boer, I.H. ; Haritunians, T. ; Lumley, T. ; Siscovick, D. ; Psaty, B.M. ; Zillikens, M.C. ; Oostra, B.A. ; Feitosa, M. ; Province, M. ; de Andrade, M. ; Turner, S.T. ; Schillert, A. ; Ziegler, A. ; Wild, P.S. ; Schnabel, R.B. ; Wilde, S. ; Munzel, T.F. ; Leak, T.S. ; Illig, T. ; Klopp, N. ; Meisinger, C. ; Wichmann, H.E. ; Koenig, W. ; Zgaga, Lina ; Zemunik, Tatijana ; Kolčić, Ivana ; Minelli, C. ; Hu, F.B. ; Johansson, A. ; Igl, W. ; Zaboli, G. ; Wild, S.H. ; Wright, A.F. ; Campbell, H. ; Ellinghaus, D. ; Schreiber, S. ; Aulchenko, Y.S. ; Felix, J.F. ; Rivadeneira, F. ; Uitterlinden, A.G. ; Hofman, A. ; Imboden, M. ; Nitsch, D. ; Brandstätter, A. ; Kollerits, B. ; Kedenko, L. ; Mägi, R. ; Stumvoll, M. ; Kovacs, P. ; Boban, M. ; Campbell, S. ; Endlich, K. ; Völzke, H. ; Kroemer, H.K. ; Nauck, M. ; Völker, U. ; Polašek, Ozren ; Vitart, V. ; Badola, S. ; Parker, A.N. ; Ridker, P.M. ; Kardia, S.L. ; Blankenberg, S. ; Liu, Y. ; Curhan, G.C. ; Franke, A. ; Rochat, T. ; Paulweber, B. ; Prokopenko, I. ; Wang, W. ; Gudnason, V. ; Shuldiner, A.R. ; Coresh, J. ; Schmidt, R. ; Ferrucci, L. ; Shlipak, M.G. ; van Duijn, C.M. ; Borecki, I. ; Krämer, B.K. ; Rudan, Igor ; Gyllensten, U. ; Wilson, J.F. ; Witteman, J.C. ; Pramstaller, P.P. ; Rettig, R. ; Hastie, N. ; Chasman, D.I. ; Kao, W.H. ; Heid, I.M. ; Fox, C.S.

Izvornik
Nature genetics (1061-4036) 42 (2010), 5; 376-384

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
chronic kidney disease; loci; SNP

Sažetak
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta- analysis of genome-wide association data in 67, 093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2) ; n = 5, 807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22, 982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita



POVEZANOST RADA


Projekt / tema
216-1080315-0293 - Genetska epidemiologija šećerne bolesti tip 1 u populaciji Hrvatske (Tatijana Zemunik, )
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )

Ustanove
Medicinski fakultet, Zagreb,
Medicinski fakultet, Split

Profili:

Avatar Url Igor Rudan (autor)

Avatar Url Ivana Kolčić (autor)

Avatar Url Ozren Polašek (autor)

Avatar Url Tatijana Zemunik (autor)

Avatar Url Lina Zgaga (autor)

Citiraj ovu publikaciju

Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V. et al.
New loci associated with kidney function and chronic kidney disease // Nature genetics, 42 (2010), 5; 376-384 doi:10.1038/ng.568 (međunarodna recenzija, članak, znanstveni)
Köttgen, A., Pattaro, C., Böger, C., Fuchsberger, C., Olden, M., Glazer, N., Parsa, A., Gao, X., Yang, Q. & Smith, A. (2010) New loci associated with kidney function and chronic kidney disease. Nature genetics, 42 (5), 376-384 doi:10.1038/ng.568.
@article{article, year = {2010}, pages = {376-384}, DOI = {10.1038/ng.568}, keywords = {chronic kidney disease, loci, SNP}, journal = {Nature genetics}, doi = {10.1038/ng.568}, volume = {42}, number = {5}, issn = {1061-4036}, title = {New loci associated with kidney function and chronic kidney disease}, keyword = {chronic kidney disease, loci, SNP} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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