engleski

The anticonvulsant action of GABA system is sex dependent

The administration of the GABA-blocking agents picrotoxin and bicuculline to adult CBA/HZgr mice resulted in the appearance of convulsions, the occurrence and/or lethality of which was greater in males than in females. The latency of picrotoxin-induced convulsions was also shorter in male mice. Strychnine, a drug which induces convulsions by blocking glycine receptors was equally effective in producing convulsions in both male and female adult mice. Unlike adult mice, young (20 days old) or old (2 years old) mice fail to display sex differences following the picrotoxin administration. Rats responded oppositely than mice, i.e., following administration of GABA-related convulsants, females were more sensitive than males.

GABA-blocking agents; mice; rats; convulsions; spinal motoneurons discharge

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