engleski

Magnesium in Patients with Bipolar Disorders

AIM To determine the concentration of total blood magnesium (tMg) and ionized magnesium (iMg) in serum of patients with bipolar disorder treated by maintenance therapy lithium carbonate (1, 2). METHODS The concentration of tMg was measured by spectrophotometric method (reference interval 0, 70 mmol/l – 1, 10 mmol/l) while the concentration of iMg was measured by ion-selective electrodes (reference interval 0, 53 mmol/l-0, 67 mmol/l). Serum of 33 patients, 30 women and 3 men, aged between 26 and 53 was tested. All of our patients were in maintenance therapy interval (0, 60-1, 2 mmol/l). The concentration of lithium carbonate in the serum was measured by flame photometry. RESULTS In all patients the obtained concentration of tMg ranged from 0, 79 mmol/l to 1, 02 mmol/l (average level 0, 90 mmol/l) and the concentration of iMg ranged from 0, 53mmol/l to 0, 77 mmol/l (average level 0, 61 mmol/l). iMg in 26/33 patients was in reference interval while higher blood levels of iMg (higher then 0, 67mmol/l) were seen in 7/33 patients.CONCLUSION Our results show that normomagnesemia measured as tMg is a common finding in patients with bipolar disorder, but when measured as iMg, about 21% patients no longer show to be normomagnesemic. This findings imply that the measurement of iMg is preferred above the routinely measured tMg.

magnesium; bipolar disorders

nije evidentirano