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Mathematical Modelling of DNA Replication in UV-Irradiated Bacteria

A mathematical model of semi-conservative DNA replication in UV-irradiated bacteria has been developed, based on the Poisson distribution of the dimers through bacterial population, uniform distribution of dimers in the chromosone, and the assumption that a pyrimidine dimer is a complete block to DNA synthesis. The model is numerically evaluated by digital simulation, using the Monte Carlo method.Compared with experimental work on DNA synthesis in UV-irradiated bacteria, the results strongly suggest that the pyrimidine dimer is not an absolute block to DNA synthesis in the absence of repair.

DNA Replication ; Pyrimidine Dimers ; Repair ; UV ; Modeling

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