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Salivary levels of TNF-alpha and IL-6 in patents with denture stomatitis before and after low-level laser therapy

Objective.The objective of this study was to monitor therapeutic response by determing the level of proinflammatory cytokines TNF-alpha and IL-6 in whole unstimulated saliva in patients with denture stomatitis before and after laser phototherapy (LPT). Bakcground. The denture stomatitis (DS) is an inflammatory condition that occurs in subjects who wear denture and it is a common oral mucosal lesion. A potential noninvasive treatment for DS patients is laser phototherapy (LPT). Methods. A sample consisting of 40 consecutive subjects was selected on a voluntary basis from patients who presented for diagnosis and treatment of DS at the Oral Medicine Unit of the Medical Faculty University of Rijeka. The clinical examination was performed according to the standard clinical criteria. Lesions were described as palatal inflammation diagnosed as Newton type II denture stomatitis. The patients were randomly assigned in experimental group (20 patients receiving real LPT) and control group (20 patients receiving inactive/placebo laser). For determination of salivary levels of TNF-alpha and IL-6, ELISA (Sigma Immunochemicals, St Louis MO, USA) was performed. Results. Following treatment with LPT for 4 weeks the levels of TNF-α and IL-6 decreased significantly ( P <0, 001) and the levels of these pro-inflammatory cytokines was significantly different from controls(P <0, 001). Conclusion. Results of this study may suggest that LPT may be an efficacious choice of therapy.

denture stomatitis; laser phototherapy

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