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Pregled bibliografske jedinice broj: 466792

Common aberrations from the normal human plasma N-glycan profile


Pučić, Maja; Pinto, Sofie; Novokmet, Mislav; Knežević, Ana; Gornik, Olga; Polašek, Ozren; Vlahoviček, Kristian; Wang, Wei; Rudd, Pauline M,; Wright, Alan F. et al.
Common aberrations from the normal human plasma N-glycan profile // Glycobiology, 20 (2010), 8; 970-975 doi:10.1093/glycob/cwq052 (međunarodna recenzija, članak, znanstveni)


Naslov
Common aberrations from the normal human plasma N-glycan profile

Autori
Pučić, Maja ; Pinto, Sofie ; Novokmet, Mislav ; Knežević, Ana ; Gornik, Olga ; Polašek, Ozren ; Vlahoviček, Kristian ; Wang, Wei ; Rudd, Pauline M, ; Wright, Alan F. ; Campbell, Harry ; Rudan, Igor ; Lauc, Gordan

Izvornik
Glycobiology (0959-6658) 20 (2010), 8; 970-975

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
protein glycosylation / N-glycans / human plasma glycome / glycan analysis

Sažetak
After performing hydrophilic interaction and weak anion exchange HPLC to analyze N-glycans in plasma of 1991 people we identified several individuals that differed significantly from the “normal” profile of N-glycans. By performing consensus scoring of pair wise distances between vectors containing measured glycan values we formed six groups of individuals with specific glyco-phenotypes. Some aberrations from the normal plasma protein patterns were found to be associated with clinical conditions (such as renal problems in people with increased monosialylated biantennary glycans, A2G2S1), while other substantial changes in N-glycan structure, such as the near complete absence of neutral glycans or antennary fucosylated tri- and tetraantennary glycans, were not associated with any observed adverse health outcomes. These results demonstrate the existence of specific altered glyco-phenotypes in some individuals, and indicate that in some cases they might represent risk factors for the development of specific diseases.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA


Projekt / tema
119-0982913-1211 - Računalna genomika mikrobnih okoliša i bioinformatika ekstremofila (Kristian Vlahoviček, )
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Ozren Polašek, )
309-0061194-2023 - Glikoproteomika stresa i bolesti povezanih sa stresom (Gordan Lauc, )

Ustanove
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Medicinski fakultet, Split,
GENOS d.o.o.

Citiraj ovu publikaciju

Pučić, Maja; Pinto, Sofie; Novokmet, Mislav; Knežević, Ana; Gornik, Olga; Polašek, Ozren; Vlahoviček, Kristian; Wang, Wei; Rudd, Pauline M,; Wright, Alan F. et al.
Common aberrations from the normal human plasma N-glycan profile // Glycobiology, 20 (2010), 8; 970-975 doi:10.1093/glycob/cwq052 (međunarodna recenzija, članak, znanstveni)
Pučić, M., Pinto, S., Novokmet, M., Knežević, A., Gornik, O., Polašek, O., Vlahoviček, K., Wang, W., Rudd, Pauline M, & Wright, A. (2010) Common aberrations from the normal human plasma N-glycan profile. Glycobiology, 20 (8), 970-975 doi:10.1093/glycob/cwq052.
@article{article, year = {2010}, pages = {970-975}, DOI = {10.1093/glycob/cwq052}, keywords = {protein glycosylation / N-glycans / human plasma glycome / glycan analysis}, journal = {Glycobiology}, doi = {10.1093/glycob/cwq052}, volume = {20}, number = {8}, issn = {0959-6658}, title = {Common aberrations from the normal human plasma N-glycan profile}, keyword = {protein glycosylation / N-glycans / human plasma glycome / glycan analysis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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