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Pregled bibliografske jedinice broj: 464370

Nasal congestion after non-isotonic aerosol inhalation is not dependent on the level of inflammation


Zurak, Krešo; Kalogjera, Livije
Nasal congestion after non-isotonic aerosol inhalation is not dependent on the level of inflammation // Zbornik sažetaka Prvog hrvatskog rinološkog kongresa / Baudoin, Tomislav (ur.).
Zagreb, 2010. (predavanje, domaća recenzija, sažetak, stručni)


CROSBI ID: 464370 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Nasal congestion after non-isotonic aerosol inhalation is not dependent on the level of inflammation

Autori
Zurak, Krešo ; Kalogjera, Livije

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Zbornik sažetaka Prvog hrvatskog rinološkog kongresa / Baudoin, Tomislav - Zagreb, 2010

Skup
Prvi hrvatski rinološki kongres

Mjesto i datum
Zagreb, Hrvatska, 25-27.02.2010

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
Allergic rhinitis; non-allergic rhinitis; nasal provocation

Sažetak
A significant increase in NAR-nasal airway resistance is observed in patients with allergic and non-allergic rhinitis after nasal provocation with distilled water mist. The purpose of the study was to compare hyperreactive response to nasal distilled water provocation in the patients with allergic and non-allergic hyperreactive rhinitis with the level of inflammatory cell activation markers prior to provocation. The study was performed on a group of 78 patients with nasal hyperreactivity based on case history, 48 patients with allergic rhinitis (AR) and 30 patients with non-infectious non-allergic rhinitis (NINAR). The concentrations of eosinophil cationic protein (ECP), myeloperoxidase (MPO) and tryptase (TRY) were measured in the nasal lavage prior to provocation. Basal nasal airway resistance (NAR) was measured by active anterior rhinomanometry, and nasal lavage with 5 ccm of saline was taken. The provocation was made by inhalation of 10 ccm of distilled water during 10 minutes delivered through a jet nebulizer. The patients were divided in three subgroups according to NAR increase (0, 50%, 100%). Tryptase concentration in the nasal lavage and a relative eosinophil number were significantly higher in allergic than non-allergic patients. No correlation was found between the relative number of eosinophils and degree of nasal hyperreactivity. Likewise no correlation was found between any of the cellular markers and level of nasal hyperreactivity, and no difference in marker levels between the groups. The correlation between ECP and MPO in nasal lavage was significant. Nasal provocation with distilled water aerosol in patients with allergic and non-allergic nasal hyperreactivity, leads to significant increase in nasal airway resistance. Degree of hyperreactive response after provocation with distilled water does not correlate with inflammatory cells activation. Probably neural reflexes leading to nasal congestion after non-isotonic aerosol inhalation are not dependent on the level of inflammation measured by the activation of granulocytes and mastocytes. Neural responses in the nose depend on activation of Sensory Ion Channels (TRP’s- Transient Receptor Potential Channels).

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
065-0650235-0145 - Istraživanje međuodnosa alergije i infekcije u rinosinuitisu i nosnoj polipozi (Kalogjera, Livije, MZOS ) ( POIROT)
108-0650235-0177 - Istraživanje kroničnog rinosinuitisa i njegova komorbiditeta (Baudoin, Tomislav, MZOS ) ( POIROT)

Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb

Profili:

Avatar Url Krešo Zurak (autor)

Avatar Url Livije Kalogjera (autor)


Citiraj ovu publikaciju

Zurak, Krešo; Kalogjera, Livije
Nasal congestion after non-isotonic aerosol inhalation is not dependent on the level of inflammation // Zbornik sažetaka Prvog hrvatskog rinološkog kongresa / Baudoin, Tomislav (ur.).
Zagreb, 2010. (predavanje, domaća recenzija, sažetak, stručni)
Zurak, K. & Kalogjera, L. (2010) Nasal congestion after non-isotonic aerosol inhalation is not dependent on the level of inflammation. U: Baudoin, T. (ur.)Zbornik sažetaka Prvog hrvatskog rinološkog kongresa.
@article{article, editor = {Baudoin, T.}, year = {2010}, pages = {82}, keywords = {Allergic rhinitis, non-allergic rhinitis, nasal provocation}, title = {Nasal congestion after non-isotonic aerosol inhalation is not dependent on the level of inflammation}, keyword = {Allergic rhinitis, non-allergic rhinitis, nasal provocation}, publisherplace = {Zagreb, Hrvatska} }
@article{article, editor = {Baudoin, T.}, year = {2010}, pages = {82}, keywords = {Allergic rhinitis, non-allergic rhinitis, nasal provocation}, title = {Nasal congestion after non-isotonic aerosol inhalation is not dependent on the level of inflammation}, keyword = {Allergic rhinitis, non-allergic rhinitis, nasal provocation}, publisherplace = {Zagreb, Hrvatska} }




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