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Pregled bibliografske jedinice broj: 464012

The Mouse Gene Noto Is Expressed in the Tail Bud and Essential for Its Morphogenesis


Žižić Mitrečić, Marica; Mitrečić, Dinko; Pochet, Roland; Kostović-Knežević, Ljiljana; Gajović, Srećko
The Mouse Gene Noto Is Expressed in the Tail Bud and Essential for Its Morphogenesis // Cells tissues organs (2010) (znanstveni, prihvaćen)


Naslov
The Mouse Gene Noto Is Expressed in the Tail Bud and Essential for Its Morphogenesis

Autori
Žižić Mitrečić, Marica ; Mitrečić, Dinko ; Pochet, Roland ; Kostović-Knežević, Ljiljana ; Gajović, Srećko

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Cells tissues organs (2010)

Status rada
Prihvaćen

Ključne riječi
notochord; Noto; tail bud; embryo; mouse

Sažetak
The mouse transcription factor Noto is expressed in the notochord and involved in its development. Noto mouse mutants, Noto(tc/tc)(truncate) and Noto(GFP/GFP) (Noto null mutant), exhibit a segmental lack of the notochord in the caudal part of the embryo and subsequent tail truncation in adult animals. In order to address the relationship between the tail bud (the undifferentiated mesenchymal cells in the tip of the embryo tail) and the caudal notochord, Noto(GFP/GFP), a loss- of-function mutant, was analyzed. Taking advantage of Noto(GFP/+) heterozygotes, we could track Noto-GFP-expressing cells from the tail bud over the tail cord to the caudal notochord, and confirm a morphological continuum from the tail bud mesenchyme to the caudal notochord. Loss of Noto affected tail bud morphogenesis: Noto-GFP-expressing cells were scattered in the tail bud mesenchyme. They segregated in the notochord-like structure within the medullary cord instead at the tail cord, which subsequently disappeared. In the tail cord, instead of the notochord, additional lumen of the tail gut was formed. These findings suggest that Noto is involved in both rearrangement and morphogenesis of the tail bud during notochord formation.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekt / tema
108-1081870-1902 - Uloga gena u diferencijaciji i plastičnosti središnjeg živčanog sustava miša (Srećko Gajović, )

Ustanove
Medicinski fakultet, Zagreb

Citiraj ovu publikaciju

Žižić Mitrečić, Marica; Mitrečić, Dinko; Pochet, Roland; Kostović-Knežević, Ljiljana; Gajović, Srećko
The Mouse Gene Noto Is Expressed in the Tail Bud and Essential for Its Morphogenesis // Cells tissues organs (2010) (znanstveni, prihvaćen)
Žižić Mitrečić, M., Mitrečić, D., Pochet, R., Kostović-Knežević, L. & Gajović, S. (2010) The Mouse Gene Noto Is Expressed in the Tail Bud and Essential for Its Morphogenesis. Prihvaćen za objavljivanje u Cells tissues organs. [Preprint].
@unknown{unknown, year = {2010}, keywords = {notochord, Noto, tail bud, embryo, mouse}, journal = {Cells tissues organs}, title = {The Mouse Gene Noto Is Expressed in the Tail Bud and Essential for Its Morphogenesis}, keyword = {notochord, Noto, tail bud, embryo, mouse} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE