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Pregled bibliografske jedinice broj: 46393

Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49)


Haberstock-Debić, Helena; Banfić, Hrvoje; Stewens, W.J.; de Clerck, L.S.; Wechung, E.; de Potter
Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49) // Neuroimmunomodulation, 4 (1997), 244-249 (podatak o recenziji nije dostupan, članak, znanstveni)


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Naslov
Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49)

Autori
Haberstock-Debić, Helena ; Banfić, Hrvoje ; Stewens, W.J. ; de Clerck, L.S. ; Wechung, E. ; de Potter

Izvornik
Neuroimmunomodulation (10217401) 4 (1997); 244-249

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
T-cell proliferation; pancrestatin; C-terminal fragment

Sažetak
We have studied the effect of pancreastatin and its C-terminal fragment (33-49) on mitogen-stimulated T lymphocyte proliferation. In a concentration range from 10(^12) to 10(^8) M they exhibit a dose-dependent stimulatory effect on concanavalin A-induced response with the maximal effect at 10(^8) M concentration. They were inactive in response to a B-cell mitogen, lipopolysaccharide, which points to an involvement of T but not B lymphocytes in their response. Pancreastatin can still produce a stimulatory effect when added 18 h after incubation of cultures with concanavalin A and apparently uses a diacylglycerol independent mechanism. When cells were preincubated for 4, 16 or 24 h with pancreastatin or its fragment and then stimulated with concanavalin A, a ten times lower concentration of peptides was needed (10(^9) M) to obtain the maximal response. This suggests that resting cells are more sensitive to pancreastatin and its fragment. Both peptides exhibit a very similar pharmacological profile, indicating that the C-terminal part of the molecule is responsible for the effect on T-cell proliferation.

Izvorni jezik
Engleski



POVEZANOST RADA


Projekti:
108013

Ustanove:
Medicinski fakultet, Zagreb


Citiraj ovu publikaciju

Haberstock-Debić, Helena; Banfić, Hrvoje; Stewens, W.J.; de Clerck, L.S.; Wechung, E.; de Potter
Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49) // Neuroimmunomodulation, 4 (1997), 244-249 (podatak o recenziji nije dostupan, članak, znanstveni)
Haberstock-Debić, H., Banfić, H., Stewens, W., de Clerck, L., Wechung, E. & de Potter (1997) Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49). Neuroimmunomodulation, 4, 244-249.
@article{article, year = {1997}, pages = {244-249}, keywords = {T-cell proliferation, pancrestatin, C-terminal fragment}, journal = {Neuroimmunomodulation}, volume = {4}, issn = {10217401}, title = {Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49)}, keyword = {T-cell proliferation, pancrestatin, C-terminal fragment} }
@article{article, year = {1997}, pages = {244-249}, keywords = {T-cell proliferation, pancrestatin, C-terminal fragment}, journal = {Neuroimmunomodulation}, volume = {4}, issn = {10217401}, title = {Stimulation of T-cell proliferation by pancreastatin and its C-terminal fragment (33-49)}, keyword = {T-cell proliferation, pancrestatin, C-terminal fragment} }

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