Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 46391

Lithium plus pilocarpine induced status epilepticus - biochemical changes


Eraković, Vesna; Župan, Gordana; Varljen, Jadranka; Laginja, Josip; Simonić, Ante
Lithium plus pilocarpine induced status epilepticus - biochemical changes // Neuroscience Research, 36 (2000), 157-166 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 46391 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Lithium plus pilocarpine induced status epilepticus - biochemical changes

Autori
Eraković, Vesna ; Župan, Gordana ; Varljen, Jadranka ; Laginja, Josip ; Simonić, Ante

Izvornik
Neuroscience Research (0168-0102) 36 (2000); 157-166

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alkaline phosphatase; aminotransferases; creatine kinase; free fatty acids; glutamate dehydrogenase; gamma-glutamyltransferase; glutathione peroxidase; lactate dehydrogenase; lithium-pilocarpine seizures; superoxide dismutase

Sažetak
The aim of the study was to investigate the changes in biochemical mechanisms facilitating cellular damages in the lithium plus pilocarpine treatment and the resulting status epilepticus. The whole brain free fatty acid (FFA) level as well as the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), glutamate dehydrogenase, aspartate-aminotransferase (AST), alanine­aminotransferase, gamma-glutamoyl transferase, alkaline phosphatase (ALP), lactate dehydrogenase (LDH) and creatine kinase in the frontal cortex, cerebellum, hippocampus and pons-medulla region of Hannover-Wistar rats were determined. The control group was intact with no previous experimental history. LiCl (125 mg/kg i.p.) was injected 20 h prior to pilocarpine (30 mg/kg i.p.) and the treated rats were sacrificed 1 or 2, 5 h after pilocarpine administration. The results show that lithium plus pilocarpine administration and the resulting status epilepticus produced the significant increase of the brain FFA content. Decreased GPX activities were detected in the frontal cortex, cerebellum and hippocampus of the treated rats without the accompanying decrease of SOD activity. Increased AST and LDH activities were observed in the frontal cortex, increased soluble ALP activities in the frontal cortex and pons-medulla region whereas the increased activity of membrane bound ALP was detected in the hippocampus of the rats with status epilepticus. Activities of the other analysed enzymes did not change in the examined brain regions. The presented data indicate clear regional differences of biochemical changes caused by lithium plus pilocarpine treatment and the resulting status epilepticus, frontal cortex being the most affected site.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
062028
062019

Ustanove:
Medicinski fakultet, Rijeka


Citiraj ovu publikaciju

Eraković, Vesna; Župan, Gordana; Varljen, Jadranka; Laginja, Josip; Simonić, Ante
Lithium plus pilocarpine induced status epilepticus - biochemical changes // Neuroscience Research, 36 (2000), 157-166 (međunarodna recenzija, članak, znanstveni)
Eraković, V., Župan, G., Varljen, J., Laginja, J. & Simonić, A. (2000) Lithium plus pilocarpine induced status epilepticus - biochemical changes. Neuroscience Research, 36, 157-166.
@article{article, year = {2000}, pages = {157-166}, keywords = {Alkaline phosphatase, aminotransferases, creatine kinase, free fatty acids, glutamate dehydrogenase, gamma-glutamyltransferase, glutathione peroxidase, lactate dehydrogenase, lithium-pilocarpine seizures, superoxide dismutase}, journal = {Neuroscience Research}, volume = {36}, issn = {0168-0102}, title = {Lithium plus pilocarpine induced status epilepticus - biochemical changes}, keyword = {Alkaline phosphatase, aminotransferases, creatine kinase, free fatty acids, glutamate dehydrogenase, gamma-glutamyltransferase, glutathione peroxidase, lactate dehydrogenase, lithium-pilocarpine seizures, superoxide dismutase} }
@article{article, year = {2000}, pages = {157-166}, keywords = {Alkaline phosphatase, aminotransferases, creatine kinase, free fatty acids, glutamate dehydrogenase, gamma-glutamyltransferase, glutathione peroxidase, lactate dehydrogenase, lithium-pilocarpine seizures, superoxide dismutase}, journal = {Neuroscience Research}, volume = {36}, issn = {0168-0102}, title = {Lithium plus pilocarpine induced status epilepticus - biochemical changes}, keyword = {Alkaline phosphatase, aminotransferases, creatine kinase, free fatty acids, glutamate dehydrogenase, gamma-glutamyltransferase, glutathione peroxidase, lactate dehydrogenase, lithium-pilocarpine seizures, superoxide dismutase} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





Contrast
Increase Font
Decrease Font
Dyslexic Font