Moderation of antidepressant response by the serotonin transporter gene (CROSBI ID 162805)
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Huezo-Diaz, Patricia ; Uher, Rudolf ; Smith, Rebecca ; Rietschel, Marcella ; Henigsberg, Neven ; Marušić , Andrej ; Mors, Ole ; Maier, Wolfgang ; Hauser, Joanna ; Souery, Daniel ; Placentino, Anna ; Zobel, Astrid ; Roj Larsen, Erik ; Czerski, Piotr M. ; Gupta, Bhanu ; Hoda, Farzana ; Perroud, Nader ; Farmer, Anne ; Craig, Ian ; Aitchison Katherine J. ; McGuffin, Peter
engleski
Moderation of antidepressant response by the serotonin transporter gene
There have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs). We hypothesised that the pharmacogenetic effect of 5-HTTLPR is modulated by gender, age and other variants in the serotonin transporter gene. Aims were to test the hypothesis that the 5- HTTLPR differently influences response to escitalopram (an SSRI) compared with nortriptyline (a noradrenaline reuptake inhibitor). The 5-HTTLPR and 13 additional markers across the serotonin transporter gene were genotyped in 795 adults with moderate-to- severe depression treated with escitalopram or nortriptyline in the Genome Based Therapeutic Drugs for Depression (GENDEP) project. The 5- HTTLPR moderated the response to escitalopram, with long-allele carriers improving more than short-allele homozygotes. A significant three- way interaction between 5-HTTLPR, drug and gender indicated that the effect was concentrated in males treated with escitalopram. The single-nucleotide polymorphism rs2020933 also influenced outcome. The effect of 5-HTTLPR on antidepressant response is SSRI specific conditional on gender and modulated by another polymorphism at the 5' end of the serotonin transporter gene.
antidepressant response; serotonin transport gene
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
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