engleski

The antimicrobial susceptibility and virulence factors of Bacillus anthracis strains isolated in Croatia

Bacillus anthracis is able to infect both livestock and humans. The importance of treatment of the disease in humans has been underscored by the bioterrorism events of 2001 in United States. Presence of PA and B/C genes (pX01 and pX02 plasmid) as well as susceptibility to several antimicrobial substances were determined in 11 strains of Bacillus anthracis isolated during two recent epizooties of anthrax occurred in Croatia in 2002 among sheep and in 2006/2007 among bovine. Plasmid pX01 plasmid observed in all of examined strains, including vaccinal Sterne strains. However plasmid pX02 was confirmed in eight out of eleven examined field strains of Bacillus anthracis while in vaccinal strains was not detected. Determination of MIC’s showed susceptibility to amoxicillin, amoxicillin with clavulanic acid, ciprofloxacin, gentamicin and tetracycline. All strains were resistant to sulfamethoxazole with trimethoprim and cefotaxime.

Bacillus anthracis / antimicrobial susceptibility / virulence factors

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