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Pregled bibliografske jedinice broj: 463466

Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions


Duraković, Nadira; Bezak, Karlo B.; Škarica, Mario; Radojčić, Vedran; Fuchs, E.J.; Murphy, G.F.; Luznik, Leo
Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions // Journal of immunology, 177 (2006), 4414-4425 (međunarodna recenzija, članak, znanstveni)


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Naslov
Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions

Autori
Duraković, Nadira ; Bezak, Karlo B. ; Škarica, Mario ; Radojčić, Vedran ; Fuchs, E.J. ; Murphy, G.F. ; Luznik, Leo

Izvornik
Journal of immunology (0022-1767) 177 (2006); 4414-4425

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Langerhans Cells; DLI; alloresponse; donor T cells

Sažetak
Mouse models of minor histocompatibility Ag-mismatched bone marrow transplantation were used to study donor dendritic cell (DC) reconstitution after conditioning, variables influencing the persistence of residual host DCs in different compartments, their phenotype, and their role in governing donor lymphocyte infusion (DLI)-mediated alloresponses. Reconstitution of all splenic DC subsets occurred rapidly after bone marrow transplantation and before T cell reconstitution. However, in contrast to MHC-mismatched chimeras, residual host-derived DCs persisted in the cutaneous lymph nodes (CLNs) of MHC-matched chimeras despite the presence or addition of donor T cells to the graft. The phenotype of these residual host-derived DCs in CLNs was consistent with Langerhans' cells (LCs). We confirmed their skin origin and found near-complete preservation of host-derived LCs in the skin. Host-derived LCs retained their ability to continuously traffic to the CLNs, expressed homogeneously increased levels of costimulatory molecules, and could capture and carry epicutaneously applied Ags. To determine the role of residual host LCs in governing DLI-mediated alloresponses, we administered DLI alone or after topical application of the TLR7 ligand imiquimod, which is known to enhance the LC emigration from the skin. DLI administration resulted in a decrease in host-derived DCs in the CLNs and increased recruitment of donor-derived DCs to the skin, whereas imiquimod augmented their alloreactivity. These results suggest uniqueness of the MHC-matched setting in relation to the persistence of host-derived DCs in the skin and points to a previously unrecognized role of host-derived LCs in the induction of DLI-mediated graft-vs-host alloresponses.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Mario Škarica (autor)

Avatar Url Nadira Duraković (autor)

Avatar Url Karlo Bezak (autor)

Avatar Url Vedran Radojčić (autor)

Citiraj ovu publikaciju

Duraković, Nadira; Bezak, Karlo B.; Škarica, Mario; Radojčić, Vedran; Fuchs, E.J.; Murphy, G.F.; Luznik, Leo
Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions // Journal of immunology, 177 (2006), 4414-4425 (međunarodna recenzija, članak, znanstveni)
Duraković, N., Bezak, K., Škarica, M., Radojčić, V., Fuchs, E., Murphy, G. & Luznik, L. (2006) Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions. Journal of immunology, 177, 4414-4425.
@article{article, year = {2006}, pages = {4414-4425}, keywords = {Langerhans Cells, DLI, alloresponse, donor T cells}, journal = {Journal of immunology}, volume = {177}, issn = {0022-1767}, title = {Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions}, keyword = {Langerhans Cells, DLI, alloresponse, donor T cells} }
@article{article, year = {2006}, pages = {4414-4425}, keywords = {Langerhans Cells, DLI, alloresponse, donor T cells}, journal = {Journal of immunology}, volume = {177}, issn = {0022-1767}, title = {Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions}, keyword = {Langerhans Cells, DLI, alloresponse, donor T cells} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE





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