Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 463434

Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse


Duraković, Nadira; Radojčić, Vedran; Škarica, Mario; Bezak, Karl B.; Powell, J.D.; Fuchs, E.J.; Luznik, Leo
Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse // Blood, 109 (2007), 10; 4564-4574 doi:10.1182/blood-2006-09-048124 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 463434 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse

Autori
Duraković, Nadira ; Radojčić, Vedran ; Škarica, Mario ; Bezak, Karl B. ; Powell, J.D. ; Fuchs, E.J. ; Luznik, Leo

Izvornik
Blood (0006-4971) 109 (2007), 10; 4564-4574

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allogeneic bone marrow transplant; donor T cells; GVL

Sažetak
Murine models of bone marrow transplantation were used to study the mechanisms governing the activation of donor lymphocyte infusions (DLIs) manifesting as lymphohematopoietic graft-versus-host (LH-GVH) and graft-versus-leukemia (GVL) reactivities. We demonstrate here that established mixed chimerism influences the potency of DLI-mediated alloreactivity only in the MHC-mismatched but not MHC-matched setting. In the MHC-matched setting, high levels (>or= 40%) of residual host chimerism correlated negatively with DLI-mediated alloreactivity irrespective of the timing of their administration, the donor's previous sensitization to host antigens, or the level of residual host APCs. In vivo administration of Toll-like receptor (TLR) ligands was required to maximize DLI-mediated LH-GVH and GVL reactivities in chimeras with low levels (<or= 15%) of residual host chimerism. In contrast, coadministration of DLI with antigen-presenting cell (APC) activators was insufficient to augment their LH-GVH response in the presence of high levels of host chimerism unless the host's T cells were transiently depleted. Together, these results show the cardinal influence of donor-host incompatibility on DLI-mediated GVH responses and suggest that in MHC-matched chimeras, the induction of optimal alloreactivity requires not only donor T cells and host APCs but also TLR ligands and in the presence of high levels of host chimerism depletion of host T cells.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
108-1081872-2061 - LIMFOPROLIFERATIVNE BOLESTI I TRANSPLANTACIJA KRVOTVORNIH MATIČNIH STANICA (Nemet, Damir, MZOS ) ( POIROT)

Ustanove:
Medicinski fakultet, Zagreb

Profili:

Avatar Url Nadira Duraković (autor)

Avatar Url Mario Škarica (autor)

Avatar Url Vedran Radojčić (autor)

Poveznice na cjeloviti tekst rada:

doi bloodjournal.hematologylibrary.org

Citiraj ovu publikaciju:

Duraković, Nadira; Radojčić, Vedran; Škarica, Mario; Bezak, Karl B.; Powell, J.D.; Fuchs, E.J.; Luznik, Leo
Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse // Blood, 109 (2007), 10; 4564-4574 doi:10.1182/blood-2006-09-048124 (međunarodna recenzija, članak, znanstveni)
Duraković, N., Radojčić, V., Škarica, M., Bezak, K., Powell, J., Fuchs, E. & Luznik, L. (2007) Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse. Blood, 109 (10), 4564-4574 doi:10.1182/blood-2006-09-048124.
@article{article, author = {Durakovi\'{c}, Nadira and Radoj\v{c}i\'{c}, Vedran and \v{S}karica, Mario and Bezak, Karl B. and Powell, J.D. and Fuchs, E.J. and Luznik, Leo}, year = {2007}, pages = {4564-4574}, DOI = {10.1182/blood-2006-09-048124}, keywords = {allogeneic bone marrow transplant, donor T cells, GVL}, journal = {Blood}, doi = {10.1182/blood-2006-09-048124}, volume = {109}, number = {10}, issn = {0006-4971}, title = {Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse}, keyword = {allogeneic bone marrow transplant, donor T cells, GVL} }
@article{article, author = {Durakovi\'{c}, Nadira and Radoj\v{c}i\'{c}, Vedran and \v{S}karica, Mario and Bezak, Karl B. and Powell, J.D. and Fuchs, E.J. and Luznik, Leo}, year = {2007}, pages = {4564-4574}, DOI = {10.1182/blood-2006-09-048124}, keywords = {allogeneic bone marrow transplant, donor T cells, GVL}, journal = {Blood}, doi = {10.1182/blood-2006-09-048124}, volume = {109}, number = {10}, issn = {0006-4971}, title = {Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse}, keyword = {allogeneic bone marrow transplant, donor T cells, GVL} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font