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Pregled bibliografske jedinice broj: 463176

Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application


Pevec, Damira; Novinščak, Tomislac; Brčić, Luka; Šipoš, Kristijan; Jukić, Ivana; Starešinić, Mario; Miše, Stjepan; Brčić, Iva; Kolenc, Danijela; Kliček, Robert et al.
Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application // Medical science monitor, 16 (2010), 3; 81-88 (međunarodna recenzija, članak, znanstveni)


Naslov
Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application

Autori
Pevec, Damira ; Novinščak, Tomislac ; Brčić, Luka ; Šipoš, Kristijan ; Jukić, Ivana ; Starešinić, Mario ; Miše, Stjepan ; Brčić, Iva ; Kolenc, Danijela ; Kliček, Robert ; Banić, Tihomir ; Sever, Marko ; Kocijan, Ana ; Berkopić, Lidija ; Radić, Božo ; Buljat, Gojko ; Anić, Tomislav ; Zoričić, Ivan ; Bojanić, Ivan ; Seiwerth, Sven ; Sikirić, Predrag

Izvornik
Medical science monitor (1234-1010) 16 (2010), 3; 81-88

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
BPC 157

Sažetak
The effect of systemic and local peptide treatment effective in muscle contusion and then on counteraction of corticosteroid-induced impairment was tested. The pentadecapeptide BPC 157, given without a carrier, improved the healing of transected quadriceps muscle. It also improved muscle healing in rats with muscle crush injury when applied systemically or locally. Importantly, it counteracted corticosteroid-impairment in tendon to bone healing. Thus BPC 157 is proposed as an effective treatment that can improve muscle healing in spite of corticosteroid treatment. After the gastrocnemius muscle complex had been injured, rats received BPC 157 (intraperitoneally or locally as a cream) and/or 6alpha-methylprednisolone (intraperitoneally) only once (immediately after injury, sacrifice at 2 h) or once daily (final dose 24 hours before sacrifice and/or assessment procedure at days 1, 2, 4, 7, and 14). Muscle healing was evaluated functionally, macroscopically, and histologically. Without therapy, crushed gastrocnemius muscle complex controls showed limited improvement. 6alpha-methylprednisolone markedly aggravated healing. In contrast, BPC 157 induced faster muscle healing and full function restoration and improved muscle healing despite systemic corticosteroid treatment when given intraperitoneally or locally and demonstrated functionally, macroscopically, and histologically at all investigated intervals. BPC 157 completely reversed systemic corticosteroid-impaired muscle healing.

Izvorni jezik
Engleski

Znanstvena područja
Biologija



POVEZANOST RADA


Projekt / tema
108-1080321-0389 - Utjecaj pentadekapeptida BPC 157 na ženski urogenitalni sustav (Hrvoje Vrčić, )
108-1083570-3611 - Pentadekapeptid BPC 157- učinkovita terapija ozljeda mišića i tetive (Božidar Šebečić, )
108-1083570-3635 - Pentadekapeptid BPC 157 - daljnja istraživanja (Predrag Sikirić, )
108-1083570-3636 - Učinak BPC 157 na induciranu bilijarnu opstrukciju (Tomislav Anić, )
108-1083570-3643 - Kvantitativna analiza i prijenos slike u patologiji (Sven Seiwerth, )

Ustanove
Medicinski fakultet, Zagreb

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Uključenost u ostale bibliografske baze podataka:


  • EMBASE (Excerpta Medica)