engleski

Possibilities and limits of treatment in patients with thrombotic thrombocytopenic purpura

Results of treatment of 18 patients fulfilling the criteria for TTP are presented. Thrombocytopenia was present in all patients (100%). Sixteen of the 18 patients (88,8%) had mental status chages, and seven of the 18 patients (38,8%) had renal impairment One patient had a secondary type of TTP, caused by non-Hodgkin's lymphoma of the large intestine (that was diagnosed later) and was excluded from the study. Immunosuppresive therapy with steroids, plasma exchange and replacement of removed volume with fresh frozen pasma in a dosege of 25 ml/kg body weight resulted in a statistically significant increase of platelet count (P=0,00222), and a significant improvement in consciousness defined by increased GCS after 2 weeks (P=0,00222). In two patients renal function recovered, and in one of them hemodialysis was no longer needed.

TTP; Plasma; exchange; outcome

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