engleski

Primary gastrointestinal non Hodgkin lymphoma in adults: clinicopathological and survival characteristics

Primary non-Hodgkin lymphomas of gastrointestinal tract (PGI-NHL) are the most common extranodal lymphomas with increasing incidence. We retrospectively analyzed, incidence, clinicopathological features as well as treatement and survival data on 39 newly diagnosed PGI-NHL (23 male, 16 female), at University Hospital „Merkur“ in order to precisely evaluate their characteristics and compare them with results of other similar studies. The most common site of PGI-NHL was the stomach ( 29 patients, 74%), followed by small intestine (5 patients, 13%), and colon and rectosigmoid ( 5 patints, 13%). According to the Ann Arboror classification 34 (87%) patients had stage IE, and IIE, and 5 patients (12%) stages III E and IVE. According World Health Organization8 (WHO) classification 29 (87%) patients had diffuse large B-cell lymphoma (DLCBL), 2 had mantle cell lymphoma, and 7 (18%) had marginal zone B- cell lymphoma-mucosa associated tissue (MALT).Twenty six patients (66%) underwent surgical resection and were later treated by chemotherapy, 10 (26%), were treated with chemotherapy alone, and 3 (8%) were treated only surgical. Complete remissione was achived in 28 patients (72% ), partial remission in 7 (18 %) Four patients had progressive disease (10%).The major prognostic factor for outcome in our patients was the stage of disease. Patients with localized lymphoma (stage IE and II E) had significantly longer overall survival (OS): 85% at 5-years and 65 % at 10 years. Patients with extended disease (stage IIIE and IV E) had overall survival less than 33%. Prognostic power of ESR, total protein and serum albumin, concentration and LDH activity, was analyzed. Among these parameters only parametars only LDH had statistically significant influence on overall survival. We conclude, that our group of patien ts is similar to other publised groups of PGI-NHL patients according to clinical characteristics as well as to pathological features. Disease stage and LDH were the only parametars that had a statistically significant influence on patients survival.

lymphoma; extranodal lymphomas; stomach; intestinal

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